...Alexander J. Martin; David A. Jans Although transport into the nucleus mediated by the importin (IMP) α/β1-heterodimer is central to viral infection, small molecule inhibitors of IMPα/β1-dependent nuclear import have only been described and shown to have antiviral activity in the last decade...

...M. Stewart Transport of macromolecules between the nuclear and cytoplasmic compartments through NPCs (nuclear pore complexes) is mediated by soluble transport factors that are commonly members of the importin-β superfamily. In the nuclear protein import cycle, importin-β binds cargo...

... © 2006 The Biochemical Society 2006 Aurora A importin microtubule mitosis Ran spindle Mitotic spindle assembly involves many factors that model the microtubule cytoskeleton into a bipolar structure consisting of three main types of microtubules. The astral microtubules emanate...