... BY) . cell homeostasis fibrosis immunometabolism inflammation macrophages monocytes The essence of the innate immune system has been tightly conserved through evolution. It includes, in addition to physical barriers such as the mucosa and skin, a series of myeloid cell subsets. Among them, Mφ...

... been placed centrally in the governance of the immune response. Termed immunometabolism, immune cells adapt cellular metabolic pathways to meet demands of activation and thus function. This rewiring influences not only the bioenergetics of the cell but altered metabolites act as signalling molecules...

... Authors; published by Portland Press Limited 2015 glycolysis glucose immunometabolism mammalian target of rapamycin complex 1 (mTORC1) natural killer cells A glycolytic metabolic state is associated with the majority of pro-inflammatory immune cells including cluster of differentiation (CD...