... agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. immune response ISG15 post translational modifications RNA viruses virus–host interactions Upon infection, viral pathogens are detected by an array of innate immune sensors distributed...

... in HIC patients. HLA-B57 can present a large range of highly conserved Gag-derived HIV peptides to CD8 + T cells and natural killer (NK) cells, both the focus of this review. So far there are limited differences in the immune response strength, magnitude, or receptor repertoire towards HIV epitopes...

.... cancer immune response major histocompatibility complex The genes encoding MHC-I are composed of the highly polymorphic class Ia ‘classical’ human leukocyte antigen genes ( HLA-A , - B and - C ) on chromosome 6 [ 16 ]. Loss of both HLA alleles results in total elimination of MHC-I expression...

..., virulence and immune response mechanisms. Mammalian EVs play an increasingly recognised role to fight infection, yet may also be commandeered to disseminate pathogens and enhance infection. EVs released by bacterial pathogens may deliver toxins to host cells, signalling molecules and new DNA to other...

... local immune responses by stimulating innate immune cells following exposure to environmental insults, pathogens, or sterile injury. Recent publications have provided new insights into how the range and duration of IL-33 activity is regulated by direct sensing of host-derived and exogenous proteolytic...

... 2017 1 6 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 biomarkers cytokines exercise oncology immune response physical training physiology Over the past 25 years, the field of clinical oncology has experienced...

...Karin Hoffmann-Sommergruber; Katharina Paschinger; Iain B.H. Wilson Both helminth infections and contact with allergens result in development of a Th2 type of immune response in the affected individual. In this context, the hygiene hypothesis suggests that reduced prevalence of parasitic infections...

...-mediated de novo formation of different proteasome compositions as i20S (immunoproteasomes) or m20S (mixed-type proteasomes) essentially supports the rapid adjustment of the mammalian immune system to pathogens. This adjustment is of particular importance for the immune response to rapidly replicating...

... that regulate leucocyte trafficking. 1 To whom correspondence should be addressed (email beat.imhof@medecine.unige.ch ). 28 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 adhesion immune response inflammation junctional adhesion molecule (JAM) leucocyte...

...@imperial.ac.uk ). 6 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 CD28 co-stimulatory molecule cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) immune response migration T-cell During an inflammatory response, leucocytes, including primed T-cells...

... 2006 © 2006 The Biochemical Society 2006 CC chemokine D6 immune response inflammation leucocyte lymphatic endothelium CCL21 CC chemokine ligand 21 CCR CC chemokine receptor DC dendritic cell GAG glycosaminoglycan References 1 Rot A. von...

... in vivo , as mice lacking D6 show exaggerated cutaneous inflammatory responses and an increased susceptibility to the development of skin cancer. CCX-CKR, on the other hand, is predicted to modulate homoeostatic lymphocyte and dendritic cell trafficking, key migratory events in acquired immune responses...

...P.J. Murray IL-1O (interleukin-10) negatively regulates inflammation through a mechanism that blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules required for the full activation of the innate and adaptive immune responses...

...S. Akira; M. Yamamoto; K. Takeda Toll-like receptors (TLRs) play a critical role in the detection of invading pathogens within the body and the subsequent immune response. Individual TLRs recognize distinct microbial components. The TLRs are a type 1 transmembrane receptor that possess...