.... Similar disruption of Ig effector function by pathogen Ig-binding proteins is evident in other species. Remarkably, all the Ig-binding proteins studied in detail to date are seen to target the CH2–CH3 domain interface in the Ig Fc region, suggesting a common mode of immune evasion. A second Ig subversion...

... ligand AICL from the cell surface ( Figure 1 F) [ 15 ], which led to degradation of AICL in an endolysosomal compartment [ 15 ]. This activity required the K5 RING-CH domain, in addition to lysine residues in the AICL cytoplasmic tail [ 15 ]. E3 ligase immune evasion K5 Kaposi's sarcoma...

... variation immune evasion RNA interference (RNAi) Trypanosoma brucei variant surface glycoprotein VSG expression site Mechanistic and Functional Studies of Proteins: A Focus Topic at BioScience2005, held at SECC Glasgow, U.K., 17–21 July 2005. Edited by S. Crosthwaite (Manchester, U.K...