... recently, the main source of morphometric data on cells has been light- and electron-based microscope images. However, many technological advances have propelled X-ray microscopy into becoming another source of high-quality morphometric information. Here, we review the status of X-ray microscopy...

... disorders such as AD (Alzheimer's disease), where the predictive validity of animal models and procedures applied preclinically have met with little success. Two approaches available for human diagnostics are currently experiencing major advancements in preclinical research: in vivo imaging using MRI...

... MRI magnetic resonance imaging MS multiple sclerosis NAWM normal-appearing white matter PPMS primary progressive MS SPMS secondary progressive MS TJ tight junction ZO-1 zonula occludens 1 References 1 Broman T. Blood-brain barrier damage...

..., and the concentrations of PtdIns(3,4) P 2 [PI(3,4)P 2 ] and PtdIns(3,4,5) P 3 (PIP 3 ) in growth factor-stimulated cells Red and blue indicate high and low levels of activity respectively. First, with the Akind probe, the activity change of Akt was time-lapse-imaged in living Cos7 cells stimulated with EGF...

... to induce neurites during neuronal development, as has been seen in the induction of membrane ruffles. Cdc42 fluorescence resonance energy transfer (FRET) GTPase-activating protein (GAP) imaging Rac Rho Rho-family GTPases function as critical molecular switches in transducing extracellular...

...M. Fehr; S. Okumoto; K. Deuschle; I. Lager; L.L. Looger; J. Persson; L. Kozhukh; S. Lalonde; W.B. Frommer To understand metabolic networks, fluxes and regulation, it is crucial to be able to determine the cellular and subcellular levels of metabolites. Methods such as PET and NMR imaging have...

...D. Tacon; P.J. Knight; M. Peckham Cellular motors (kinesin, dynein and myosin) are ubiquitous. A major task in cell biology is to determine how they function in cells. Here we focus on myosin 10, an intrafilopodial motor, and show how imaging green fluorescent protein fused to myosin 10 or its tail...

... interactions of many kinds of molecular species. The possibilities for making single-cell spatial imaging measurements of such interactions is also described. Examples are used to indicate the feasibility of identifying and tracking localized interactions on the membrane surface in real-time. Some of this work...