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Keywords: hypoxia-inducible factor (HIF)
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Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... hypoxia-inducible factor (HIF) inflammation vascular endothelial growth factor (VEGF) In 1979, Dvorak et al. [ 1 ] reported the discovery of a new molecule they called VPF (vascular permeability factor). It was later renamed VEGF (vascular endothelial growth factor) [ 2 ]. This molecule became...
Biochem Soc Trans (2011) 39 (2): 492–494.
Published: 22 March 2011
... inhibitors of mTOR in RCC. 1 To whom correspondence should be addressed (email olivier.dormond@chuv.ch ). 8 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 ATP-competitive inhibitor hypoxia-inducible factor (HIF) mammalian target of rapamycin (mTOR...
Biochem Soc Trans (2008) 36 (3): 472–478.
Published: 21 May 2008
... renal cell carcinoma hypoxia-inducible factor (HIF) renal cancer tumour suppressor von Hippel–Lindau ( VHL ) von Hippel–Lindau protein (pVHL) The familial cancer syndrome, VHL (von Hippel–Lindau) disease, occurs as a consequence of inheriting a mutation in the VHL tumour-suppressor gene...
Biochem Soc Trans (2003) 31 (3): 510–515.
Published: 01 June 2003
... encoding vascular endothelial growth factor and erythropoietin. The hypoxic response is mediated by hypoxia-inducible factor (HIF), an αβ heterodimeric transcription factor in which both the HIF subunits are members of the basic helix–loop–helix PAS (PER-ARNT-SIM) domain family. Under hypoxic conditions...