... hypoxia-inducible factor (HIF) inflammation vascular endothelial growth factor (VEGF) In 1979, Dvorak et al. [ 1 ] reported the discovery of a new molecule they called VPF (vascular permeability factor). It was later renamed VEGF (vascular endothelial growth factor) [ 2 ]. This molecule became...

... inhibitors of mTOR in RCC. 1 To whom correspondence should be addressed (email olivier.dormond@chuv.ch ). 8 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 ATP-competitive inhibitor hypoxia-inducible factor (HIF) mammalian target of rapamycin (mTOR...

... renal cell carcinoma hypoxia-inducible factor (HIF) renal cancer tumour suppressor von Hippel–Lindau ( VHL ) von Hippel–Lindau protein (pVHL) The familial cancer syndrome, VHL (von Hippel–Lindau) disease, occurs as a consequence of inheriting a mutation in the VHL tumour-suppressor gene...

... encoding vascular endothelial growth factor and erythropoietin. The hypoxic response is mediated by hypoxia-inducible factor (HIF), an αβ heterodimeric transcription factor in which both the HIF subunits are members of the basic helix–loop–helix PAS (PER-ARNT-SIM) domain family. Under hypoxic conditions...