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Keywords: hypoxia
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Biochem Soc Trans (2021) 49 (3): 1251–1263.
Published: 18 May 2021
...Hannah Bolland; Tiffany S. Ma; Syafiq Ramlee; Kristijan Ramadan; Ester M. Hammond Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O 2 ) cells become up to three times more resistant to radiation. The biological response...
Includes: Supplementary data
Biochem Soc Trans (2021) 49 (1): 17–27.
Published: 18 February 2021
... of the role of CHCHD4 and the DRS in physiology and disease, with a specific focus on the emerging importance of CHCHD4 in regulating the cellular response to low oxygen (hypoxia) and metabolism in cancer. Correspondence: Margaret Ashcroft ( m.ashcroft@medschl.cam.ac.uk ) 19 11 2020 19 12...
Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
... of oncometabolites. We also describe emerging evidence that these enzymes are responsive to cellular stresses including hypoxia and DNA damage. Moreover, we examine how dysregulation of 2OG-dependent oxygenases is associated with human disease, and the apparent paradoxical role for some of these enzymes during...
Biochem Soc Trans (2020) 48 (3): 1121–1128.
Published: 05 May 2020
...Michael Batie; Sonia Rocha Oxygen sensing is an essential feature of metazoan biology and reductions in oxygen availability (hypoxia) have both physiological and pathophysiological implications. Co-ordinated mechanisms have evolved for sensing and responding to hypoxia, which involve diverse...
Biochem Soc Trans (2018) 46 (3): 599–607.
Published: 20 April 2018
...Andrew J. Murray; Hugh E. Montgomery; Martin Feelisch; Michael P.W. Grocott; Daniel S. Martin Ascent to high altitude is associated with physiological responses that counter the stress of hypobaric hypoxia by increasing oxygen delivery and by altering tissue oxygen utilisation via metabolic...
Biochem Soc Trans (2016) 44 (4): 1111–1116.
Published: 15 August 2016
...) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations. cancer metabolism fumarate hydratase hypoxia isocitrate dehydrogenase reactive oxygen species (ROS) succinate dehydrogenase Dysfunction in IDH, SDH and FH are also involved...
Biochem Soc Trans (2014) 42 (2): 457–460.
Published: 20 March 2014
... hypoxia proteostasis unfolded protein response (UPR) In conclusion, we highlighted the renoprotective effect of Glo1 via reduction of oxidative and glycative stress, which induced pathogenic alteration of post-translational modification. Protein homoeostasis, or proteostasis, is conducted...
Biochem Soc Trans (2013) 41 (5): 1325–1330.
Published: 23 September 2013
...) mitochondrial complex I hypoxia ischaemia thiol modification thiol nitrosation Production of energy in most aerobic cells is provided by the combined action of the mitochondrial respiratory chain and ATP synthase. Reducing equivalents from pyridine nucleotides (NADH) generated in several catabolic...
Biochem Soc Trans (2013) 41 (2): 657–663.
Published: 21 March 2013
...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...
Biochem Soc Trans (2013) 41 (1): 273–276.
Published: 29 January 2013
... promote tumor progression Cancer Res. 2012 72 4920 4930 15 Brown J.M. Wilson W.R. Exploiting tumour hypoxia in cancer treatment Nat. Rev. 2004 4 437 447 16 Evans S.M. Judy K.D. Dunphy I. Jenkins W.T. Hwang W.T. Nelson P.T. Lustig R.A...
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... capillarity by more than 50%, (ii) decreases exercise endurance time by approximately 80%, and (iii) abolishes the angiogenic response to exercise training. What causes VEGF to increase with exercise is not clear. Despite regulation by HIF (hypoxia-inducible factor), increased HIF on exercise, and P O 2...
Biochem Soc Trans (2009) 37 (6): 1221–1227.
Published: 19 November 2009
... and metalloproteinase Dll1 Delta-like 1 Flt4 Fms-like tyrosine kinase 4 HIF-1 hypoxia-inducible factor-1 FIH-1 factor inhibiting HIF-1α Jag1 Jagged-1 kdr kinase insert domain-containing receptor NICD Notch intracellular domain Nrarp Notch-regulated ankyrin repeat protein...
Biochem Soc Trans (2009) 37 (1): 284–288.
Published: 20 January 2009
... kinase (eEF2k) eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) hypoxia mammalian target of rapamycin (mTOR) stress translation mTOR is involved in two mutually exclusive complexes, mTORC1 and mTORC2. mTORC2 phosphorylates and activates Akt, whereas mTORC1 activates translation...
Biochem Soc Trans (2008) 36 (3): 445–448.
Published: 21 May 2008
... deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function. 1 To whom correspondence should be addressed (email cormac.taylor...
Biochem Soc Trans (2007) 35 (5): 905–907.
Published: 25 October 2007
.... Furthermore, transfection with MMP-2 and MT1-MMP promotes their invasive potential. cardiac fibroblast collagen hypoxia invasion matrix metalloproteinase (MMP) myocardial remodelling The adult heart consists of myocytes, connected and surrounded by an extracellular collagen matrix [ECM...
Biochem Soc Trans (2005) 33 (6): 1394–1396.
Published: 26 October 2005
... cell death can be distinguished: (i) energy depletion-induced necrosis and (ii) oxidant-induced apoptosis [ 2 ]. NO-induced cell death can be induced either (a) by NO itself directly (mainly via inhibition of cytochrome oxidase, in which case death is promoted by hypoxia and low glycolysis) or (b...
Biochem Soc Trans (2005) 33 (5): 1078–1081.
Published: 26 October 2005
... ). 11 7 2005 © 2005 The Biochemical Society 2005 adipokine adipose tissue cytokine hypoxia inflammation metabolic syndrome The expression, production and release of a number of inflammation-related adipokines is increased in adipose tissue with obesity, including TNFα, IL-6...
Biochem Soc Trans (2005) 33 (5): 1137–1139.
Published: 26 October 2005
...L. Callinan; T.V. McCarthy; Y. Maulet; J.J. Mackrill One type of cellular response to hypoxia is an increase in cytosolic Ca 2+ . VDCCs (voltage-dependent calcium channels) open upon membrane depolarization allowing inward current of Ca 2+ ions. Two of the so-called L-type VDCC α1 subunits, Ca v...
Biochem Soc Trans (2004) 32 (6): 1068–1069.
Published: 26 October 2004
... inducible NOS (nitric oxide synthase) highly sensitizes neurons to hypoxia-induced death, probably via the NO–oxygen competition at cytochrome oxidase. Thus the NO from neuronal NOS during excitotoxicity or the NO from inducible NOS during inflammation may sensitize the brain to hypoxic/ischaemic damage...
Biochem Soc Trans (2004) 32 (6): 943–945.
Published: 26 October 2004
...D.E. Lancaster; M.A. McDonough; C.J. Schofield FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl β-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor...
Biochem Soc Trans (2003) 31 (3): 510–515.
Published: 01 June 2003
...K.S. Hewitson; L.A. McNeill; J.M. Elkins; C.J. Schofield Sensing of ambient dioxygen levels and appropriate feedback mechanisms are essential processes for all multicellular organisms. In animals, moderate hypoxia causes an increase in the transcription levels of specific genes, including those...
Biochem Soc Trans (2001) 29 (2): 42–48.
Published: 01 May 2001
... Russ.Anthony@Colostate.edu ) 13 12 2000 © 2001 Biochemical Society 2001 angiogenesis hypoxia intrauterine growth restriction placental lactogen transcription Ang, angiopoietin AP, activator protein bHLH, basis helix-loop-helix CSEn, chorionic somatomammotropin gene enhancer...
Biochem Soc Trans (2001) 29 (2): 86–90.
Published: 01 May 2001
... fetal growth retardation placenta pre-eclampsia perfusion hypoxia CNS, central nervous system hCG, human chorionic gonadotropin hPL, human placental lactogen IUGR, intra-uterine growth retardation Biochemical Society Transactions (200 I) Volume 29, part 2 Physiological and pathological...