... into the role of PKD in hypertrophic signalling pathways. 1 To whom correspondence should be addressed (email y.sin.1@research.gla.ac.uk ). 14 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 fetal gene programme histone deacetylase 5 (HDAC5) hypertrophy...

... that the synapses that were visualized as the animal progressed to end-stage disease were undergoing hypertrophy. Similar findings in samples from AD (Alzheimer's disease) patients, aged and senile individuals, and animal models of neurodegenerative diseases suggest synaptic swelling as synaptic loss is initiated...

... emerin Emery–Dreifuss muscular dystrophy (EDMD) hypertrophy lamin A/C At the NE (nuclear envelope), multiprotein complexes exist that function to maintain nuclear integrity, regulate gene transcription and DNA replication. The composition of these protein complexes appears to be cell-type...

... be addressed (email m.g.mackenzie@dundee.ac.uk ). 6 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 hypertrophy mammalian target of rapamycin (mTOR) protein degradation protein synthesis resistance exercise vacuolar protein sorting mutant 34 (Vps34...

... of phenotypic remodelling during hypertrophy. The increase in Ca 2+ that drives the larger contractions may be responsible for switching on a second process of signalosome remodelling to down-regulate the Ca 2+ signalling pathway. It is a change in the properties of the Ca 2+ transient that seems to carry...

... (GPCR) heart disease hypertrophy phosphoinositide 3-kinase γ (PI3Kγ) Abbreviations used: β-AR, β-adrenergic receptor; GPCR, G-protein-coupled receptor; PAF, platelet-activating factor; PI3K, phosphoinositide 3-kinase; PKB, protein kinase B; PTEN, phosphatase and tensin homologue deleted...