... 2014 Biochemical Society 2014 coenzyme A diabetes fuel oxidation hyperglycaemia leptin-deficient mouse CoA (coenzyme A) is an essential and universally distributed cofactor that plays a central role in energy metabolism. This molecule contains an active thiol moiety that forms...

... (email alan.cherrington@vanderbilt.edu ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 glucagon hyperglycaemia insulin intralipid liver somatostatin Insulin is well recognized as a potent inhibitor of hepatic glucose production...

... rates of superoxide production in β cells with lower mitochondrial metabolic activity contributed to the susceptibility of these cells to apoptosis. Chronic hyperglycaemia has been shown to cause diabetic lesions in retina, nerves, kidney and vascular endothelial cells and is also suspected...

...M. Bourajjaj; C.D.A. Stehouwer; V.W.M. van Hinsbergh; C.G. Schalkwijk Various theories have been proposed to explain the hyperglycaemia-induced pathogenesis of vascular complications of diabetes, including detrimental effects of AGEs (advanced glycation end products) on vascular tissues. Increased...