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Keywords: hydroxylation
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Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
...Sally C. Fletcher; Mathew L. Coleman Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases are a conserved enzyme class that catalyse diverse oxidative reactions across nature. In humans, these enzymes hydroxylate a broad range of biological substrates including DNA, RNA, proteins and some metabolic...
Biochem Soc Trans (2014) 42 (4): 945–951.
Published: 11 August 2014
...Margreet C.M. Vissers; Caroline Kuiper; Gabi U. Dachs There is growing interest in the family of 2-OG (2-oxoglutarate)-dependent dioxygenase enzymes that catalyse the hydroxylation of a wide range of organic targets. Members of this family that regulate the cell's hypoxic response and epigenetic...
Biochem Soc Trans (2004) 32 (6): 943–945.
Published: 26 October 2004
...D.E. Lancaster; M.A. McDonough; C.J. Schofield FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl β-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor...