... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 hydrogen peroxide peroxiredoxins redox signalling thiol oxidation Hydrogen peroxide is produced as a by-product of mitochondrial respiration and an end product of many metabolic...

...Mark A. Watson; Hoi-Shan Wong; Martin D. Brand Changes in mitochondrial superoxide and hydrogen peroxide production may contribute to various pathologies, and even aging, given that over time and in certain conditions, they damage macromolecules and disrupt normal redox signalling. Mitochondria...

...Elizabeth A. Veal; Lewis E. Tomalin; Brian A. Morgan; Alison M. Day As a more selectively reactive oxygen species, H 2 O 2 (hydrogen peroxide) has been co-opted as a signalling molecule, but high levels can still lead to lethal amounts of cell damage. 2-Cys Prxs (peroxiredoxins) are ubiquitous...

...Rachel E. Martin; Zhenbo Cao; Neil J. Bulleid Hydrogen peroxide (H 2 O 2 ) can act as a signalling molecule affecting the cell cycle as well as contributing towards the oxidative stress response. The primary target of this molecule is oxidation-sensitive cysteine residues in proteins...

... correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...

... meningitis. Following activation, macrophages produce superoxide (O 2 − ), hydrogen peroxide (H 2 O 2 ) and nitric oxide (NO). The toxicity of O 2 − , generated using X/Xo (xanthine/xanthine oxidase), and H 2 O 2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-( N , N...

... and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a key ROS, apparently through interactions with redox-active metal ions. Our recent results suggest that ROS are generated during the very early stages of protein aggregation, when protofibrils or soluble oligomers...

... 2004 hydrogen peroxide phosphatase protein tyrosine phosphatase (PTP) reactive oxygen species (ROS) redox signalling superoxide Regulated reversible phosphorylation of proteins and other cellular molecules plays a ubiquitous role in the control of cellular behaviour. Several different...

... Meeting held at New Edinburgh Royal Infirmary, Little France, Nr. Edinburgh, 19–20 November 2003 12 December 2003 © 2004 Biochemical Society 2004 apoptosis hydrogen peroxide neutrophil phosphatidylserine vitamin C Abbreviations used: CGD, chronic granulomatous disease...

... be addressed (e-mail hans.nohl@vu-wien.ac.at ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 ATPase activity bc 1 complex glutathione hydrogen peroxide mitochondria superoxide...

... Society 2001 gene expression hydrogen peroxide MAP kinases NADPH oxidase signal transduction MAP kinase, mitogen-activated protein kinase NF-κB, nuclear factor-κB NOH, NADPH oxidase homologue ROS, reactive oxygen species SOD, superoxide dismutase Biochemical and Biomedical Aspects...