... for facilitated or directed oxidation of specific targets. These findings help define conditions that enable redox signalling but there is still much to learn regarding mechanisms. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 hydrogen peroxide...

...Mark A. Watson; Hoi-Shan Wong; Martin D. Brand Changes in mitochondrial superoxide and hydrogen peroxide production may contribute to various pathologies, and even aging, given that over time and in certain conditions, they damage macromolecules and disrupt normal redox signalling. Mitochondria...

...Elizabeth A. Veal; Lewis E. Tomalin; Brian A. Morgan; Alison M. Day As a more selectively reactive oxygen species, H 2 O 2 (hydrogen peroxide) has been co-opted as a signalling molecule, but high levels can still lead to lethal amounts of cell damage. 2-Cys Prxs (peroxiredoxins) are ubiquitous...

...Rachel E. Martin; Zhenbo Cao; Neil J. Bulleid Hydrogen peroxide (H 2 O 2 ) can act as a signalling molecule affecting the cell cycle as well as contributing towards the oxidative stress response. The primary target of this molecule is oxidation-sensitive cysteine residues in proteins...

... correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...

... meningitis. Following activation, macrophages produce superoxide (O 2 − ), hydrogen peroxide (H 2 O 2 ) and nitric oxide (NO). The toxicity of O 2 − , generated using X/Xo (xanthine/xanthine oxidase), and H 2 O 2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-( N , N...

... and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a key ROS, apparently through interactions with redox-active metal ions. Our recent results suggest that ROS are generated during the very early stages of protein aggregation, when protofibrils or soluble oligomers...

... studies should give us a clearer picture of the role of phosphatase inactivation in cellular behaviour and explain how specificity is achieved in redox signalling. 8 7 2004 © 2004 The Biochemical Society 2004 hydrogen peroxide phosphatase protein tyrosine phosphatase (PTP) reactive...

... shown that ascorbate can enhance apoptosis in endothelial cells in the presence of chlorinated oxidants [6]. To determine Key words: apoptosis, hydrogen peroxide, neutrophil, phosphatidylserine, vitamin C. Abbreviations used: CGD, chronic granulomatous disease; DPI, diphenyleneiodonium; PS...

... oxygen species; UQH 2 , ubiquinol. ATPase activity bc 1 complex glutathione hydrogen peroxide mitochondria superoxide radical © 2003 Biochemical Society 2003 4 July 2003 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July...

... Society 2001 gene expression hydrogen peroxide MAP kinases NADPH oxidase signal transduction MAP kinase, mitogen-activated protein kinase NF-κB, nuclear factor-κB NOH, NADPH oxidase homologue ROS, reactive oxygen species SOD, superoxide dismutase Biochemical and Biomedical Aspects...