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Keywords: homologous recombination
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Biochem Soc Trans (2024) 52 (1): 367–377.
Published: 07 February 2024
...Jingyi Hu; J. Brooks Crickard Homologous recombination (HR) is a template-based DNA double-strand break repair pathway that functions to maintain genomic integrity. A vital component of the HR reaction is the identification of template DNA to be used during repair. This occurs through a mechanism...
Biochem Soc Trans (2023) 51 (2): 527–538.
Published: 09 March 2023
... and obstructed DNA termini for DNA repair by end joining or homologous recombination, yet leaves undamaged DNA intact. Recent years have brought progress in both the structural and functional analyses of Mre11–Rad50 orthologs, revealing mechanisms of DNA end recognition, endo/exonuclease activities, nuclease...
Biochem Soc Trans (2018) 46 (6): 1643–1651.
Published: 04 December 2018
... damage response pathways as key regulators of fork stability. Homologous recombination factors such as RAD51, BRCA1, and BRCA2, along with components of the Fanconi Anemia pathway, are now known to be crucial for stabilizing stalled replication forks and preventing nascent strand degradation. Several...
Biochem Soc Trans (2013) 41 (6): 1726–1730.
Published: 20 November 2013
... going by the names of MHF1 (FANC M -associated h istone- f old protein 1) and MHF2 respectively. In this guise they function with a DNA translocase called FANCM (Fanconi’s anemia complementation group M) to promote DNA repair and homologous recombination. In the present review we discuss current...
Biochem Soc Trans (2012) 40 (1): 173–178.
Published: 19 January 2012
...Johanne M. Murray; Tom Stiff; Penny A. Jeggo DNA DSBs (double-strand breaks) represent a critical lesion for a cell, with misrepair being potentially as harmful as lack of repair. In mammalian cells, DSBs are predominantly repaired by non-homologous end-joining or homologous recombination...
Biochem Soc Trans (2011) 39 (1): 15–19.
Published: 19 January 2011
...Malcolm F. White The process of information exchange between two homologous DNA duplexes is known as homologous recombination (HR) or double-strand break repair (DSBR), depending on the context. HR is the fundamental process underlying the genome shuffling that expands genetic diversity...
Biochem Soc Trans (2009) 37 (3): 597–604.
Published: 20 May 2009
...) DNA-damage response double-strand break Fanconi's anaemia homologous recombination ubiquitination BRCA1 is an important tumour-suppressor gene. Germline mutations in BRCA1 are present in nearly 50% of inherited breast cancer cases, and the acquisition of a single defective allele leads...
Biochem Soc Trans (2009) 37 (1): 102–107.
Published: 20 January 2009
...Sam Haldenby; Malcolm F. White; Thorsten Allers Recombinases of the RecA family are essential for homologous recombination and underpin genome stability, by promoting the repair of double-stranded DNA breaks and the rescue of collapsed DNA replication forks. Until now, our understanding...
Biochem Soc Trans (2007) 35 (5): 1352–1354.
Published: 25 October 2007
... cancer therapy DNA replication homologous recombination poly(ADP-ribose) polymerase (PARP) repair tumorigenesis During every round of DNA replication, moving replication forks encounter countless obstacles and lesions on the DNA template, such as DNA-bound proteins, difficult to replicate...
Biochem Soc Trans (2006) 34 (4): 537–541.
Published: 21 July 2006
...A. Lorenz; M.C. Whitby Homologous recombination is an important mechanism for the repair of double-strand breaks in DNA. One possible outcome of such repair is the reciprocal exchange or crossing over of DNA between chromosomes. Crossovers are beneficial during meiosis because, as well...
Biochem Soc Trans (2006) 34 (4): 523–525.
Published: 21 July 2006
...S. Keeney; M.J. Neale Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining...
Biochem Soc Trans (2006) 34 (4): 542–544.
Published: 21 July 2006
... crossover interference double Holliday junction homologous recombination meiosis mismatch repair Meiosis is a specialized form of cell division during which a single round of DNA replication is followed by two cell divisions thereby reducing the chromosome content from diploid to haploid...
Biochem Soc Trans (2005) 33 (1): 59–60.
Published: 01 February 2005
... The Biochemical Society 2005 deletion mutant Desulfovibrio vulgaris homologous recombination hydrogenase sulphate-reducing bacteria Desulfovibrio is an anaerobic, sulphate-reducing member of the δ-proteobacteria [ 1 , 2 ], which is ubiquitously found in Nature. DvH ( Desulfovibrio vulgaris...
Biochem Soc Trans (2004) 32 (6): 959–961.
Published: 26 October 2004
... (email t.helleday@sheffield.ac.uk ). 13 7 2004 © 2004 The Biochemical Society 2004 cancer treatment DNA repair homologous recombination poly(ADP-ribose) polymerase replication The abundant nuclear protein PARP is the most well-characterized member of a family of enzymes...