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Keywords: homologous recombination
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Articles
Biochem Soc Trans (2018) 46 (6): 1643–1651.
Published: 04 December 2018
... damage response pathways as key regulators of fork stability. Homologous recombination factors such as RAD51, BRCA1, and BRCA2, along with components of the Fanconi Anemia pathway, are now known to be crucial for stabilizing stalled replication forks and preventing nascent strand degradation. Several...
Articles
Biochem Soc Trans (2013) 41 (6): 1726–1730.
Published: 20 November 2013
... going by the names of MHF1 (FANC M -associated h istone- f old protein 1) and MHF2 respectively. In this guise they function with a DNA translocase called FANCM (Fanconi’s anemia complementation group M) to promote DNA repair and homologous recombination. In the present review we discuss current...
Articles
Biochem Soc Trans (2012) 40 (1): 173–178.
Published: 19 January 2012
...Johanne M. Murray; Tom Stiff; Penny A. Jeggo DNA DSBs (double-strand breaks) represent a critical lesion for a cell, with misrepair being potentially as harmful as lack of repair. In mammalian cells, DSBs are predominantly repaired by non-homologous end-joining or homologous recombination...
Articles
Biochem Soc Trans (2011) 39 (1): 15–19.
Published: 19 January 2011
...Malcolm F. White The process of information exchange between two homologous DNA duplexes is known as homologous recombination (HR) or double-strand break repair (DSBR), depending on the context. HR is the fundamental process underlying the genome shuffling that expands genetic diversity...
Articles
Biochem Soc Trans (2009) 37 (3): 597–604.
Published: 20 May 2009
... about its interactions with other proteins, its biochemical activity and its nuclear localization. breast cancer 1 early-onset (BRCA1) DNA-damage response double-strand break Fanconi's anaemia homologous recombination ubiquitination BRCA1 is an important tumour-suppressor gene...
Articles
Biochem Soc Trans (2009) 37 (1): 88–91.
Published: 20 January 2009
...Dennis W. Grogan HR (homologous recombination) is expected to play important roles in the molecular biology and genetics of archaea, but, so far, few functional properties of archaeal HR have been measured in vivo . In the extreme thermoacidophile Sulfolobus acidocaldarius , a conjugational...
Articles
Biochem Soc Trans (2009) 37 (1): 102–107.
Published: 20 January 2009
...Sam Haldenby; Malcolm F. White; Thorsten Allers Recombinases of the RecA family are essential for homologous recombination and underpin genome stability, by promoting the repair of double-stranded DNA breaks and the rescue of collapsed DNA replication forks. Until now, our understanding...
Articles
Biochem Soc Trans (2007) 35 (5): 1352–1354.
Published: 25 October 2007
... cancer therapy DNA replication homologous recombination poly(ADP-ribose) polymerase (PARP) repair tumorigenesis During every round of DNA replication, moving replication forks encounter countless obstacles and lesions on the DNA template, such as DNA-bound proteins, difficult to replicate...
Articles
Biochem Soc Trans (2006) 34 (4): 537–541.
Published: 21 July 2006
...A. Lorenz; M.C. Whitby Homologous recombination is an important mechanism for the repair of double-strand breaks in DNA. One possible outcome of such repair is the reciprocal exchange or crossing over of DNA between chromosomes. Crossovers are beneficial during meiosis because, as well...
Articles
Biochem Soc Trans (2006) 34 (4): 523–525.
Published: 21 July 2006
...S. Keeney; M.J. Neale Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining...
Articles
Biochem Soc Trans (2006) 34 (4): 542–544.
Published: 21 July 2006
... crossover interference double Holliday junction homologous recombination meiosis mismatch repair Meiosis is a specialized form of cell division during which a single round of DNA replication is followed by two cell divisions thereby reducing the chromosome content from diploid to haploid...
Articles
Biochem Soc Trans (2005) 33 (6): 1447–1450.
Published: 26 October 2005
...M.A. Macris; P. Sung Homologous recombination (HR) is a major pathway for the elimination of DNA DSBs (double-strand breaks) induced by high-energy radiation and chemicals, or that arise due to endogenous damage and stalled DNA replication forks. If not processed properly, DSBs can lead to cell...
Articles
Biochem Soc Trans (2005) 33 (1): 59–60.
Published: 01 February 2005
...; [ 8 ]). To elucidate further the roles of the various hydrogenases, and allow future site-directed mutagenesis, we have constructed a knockout mutant of the hynAB genes for [NiFe] hydrogenase isoenzyme 1 in DvH by homologous recombination, employing a similar procedure as described for deletion...
Articles
Biochem Soc Trans (2004) 32 (6): 959–961.
Published: 26 October 2004
... (email t.helleday@sheffield.ac.uk ). 13 7 2004 © 2004 The Biochemical Society 2004 cancer treatment DNA repair homologous recombination poly(ADP-ribose) polymerase replication The abundant nuclear protein PARP is the most well-characterized member of a family of enzymes...