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Keywords: histone
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Articles
Biochem Soc Trans (2016) 44 (4): 979–986.
Published: 15 August 2016
...James A.L. Brown; Emer Bourke; Leif A. Eriksson; Michael J. Kerin Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de...
Articles
Biochem Soc Trans (2013) 41 (3): 697–699.
Published: 23 May 2013
..., and a flurry of new studies are underway to uncover its significance. Epigenetics is not confined to a study of DNA, and the post-translational modifications on the histone proteins have a significant role to play in regulating gene expression. There are many different modifications and, as shown...
Articles
Biochem Soc Trans (2013) 41 (3): 761–768.
Published: 23 May 2013
...Geoff Gudavicius; Heddy Soufari; Santosh Upadhyay; Cameron D. Mackereth; Christopher J. Nelson Peptidylprolyl isomerases have been implicated in chromatin regulation through their association with histones, chromatin-modifying enzymes and DNA-binding transcription factors. As with other post...
Articles
Biochem Soc Trans (2013) 41 (3): 789–796.
Published: 23 May 2013
... expression programme is largely driven through epigenetic mechanisms such as post-translational histone modifications and DNA methylation. In the last few years, the distinct functions of histone modifications and of the enzymes catalysing their formation have begun to be elucidated in processes important...
Articles
Biochem Soc Trans (2012) 40 (2): 357–363.
Published: 21 March 2012
...Wallace H. Liu; Mair E.A. Churchill The eukaryotic processes of nucleosome assembly and disassembly govern chromatin dynamics, in which histones exchange in a highly regulated manner to promote genome accessibility for all DNA-dependent processes. This regulation is partly carried out by histone...
Articles
Biochem Soc Trans (2012) 40 (2): 335–340.
Published: 21 March 2012
... organization, simply defined as the distinction between coding and non-coding regions, and chromatin structure in budding yeast and that the dominant effect is not the sequence-directed positioning of nucleosomes at specific sites [ 4 ], but instead the preferential exclusion of histone octamers from...
Articles
Biochem Soc Trans (2008) 36 (4): 732–737.
Published: 22 July 2008
... nucleosomes reveals a reversible multistage release of DNA Proc. Natl. Acad. Sci. U.S.A. 2002 99 1960 1965 15 Sterner D.E. Berger S.L. Acetylation of histones and transcription-related factors Microbiol. Mol. Biol. Rev. 2000 64 435 459 16 Brower-Toland B. Wacker D.A...
Articles
Biochem Soc Trans (2007) 35 (3): 609–611.
Published: 22 May 2007
... chromosomes to the locations characteristic of mature spermatozoa [ 14 ]. centromere chromosome epigenetic information histone male pronucleus spermatozoon Dramatic reorganization of chromosomes occurs during mammalian spermatogenesis due to gradual replacement of histones first...
Articles
Biochem Soc Trans (2003) 31 (5): 893–905.
Published: 01 October 2003
...@dundee.ac.uk 19 May 2003 © 2003 Biochemical Society 2003 chromatin chromatin-remodelling enzyme DNA histone nucleosome Abbreviations used: CSF-1, colony-stimulating factor-1; ISWI, imitation switch; SNF, sucrose non-fermenting; SWI, switching (of yeast mating-type). Colw...
Articles
Biochem Soc Trans (2003) 31 (4): 741–743.
Published: 01 August 2003
...T. Kouzarides In recent years, our view of how gene expression is controlled has changed dramatically. The discovery of enzymes that modify histones has revealed that transcription is an enzymically driven process. Such modifications can recruit specific proteins and mediate chromatin changes...