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Keywords: hippocampus
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Articles
Biochem Soc Trans (2009) 37 (6): 1323–1327.
Published: 19 November 2009
... -aspartate) receptors] to spatial memory. Studies with GluN2 NMDAR mutants have revealed different contributions from GluN2A- and GluN2B-containing NMDARs to spatial learning. Furthermore, comparison of forebrain- and hippocampus-specific GluN2B-knockout mice has demonstrated that both hippocampal and extra...
Articles
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
... from hippocampal CA1 synapses. The impact of these leptin-driven changes on hippocampal excitatory synaptic function are discussed. α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPA receptor) hippocampus leptin N -methyl- D -aspartate receptor (NMDA receptor) synaptic...
Articles
Biochem Soc Trans (2009) 37 (6): 1359–1363.
Published: 19 November 2009
... with PtdIns(4,5) P 2 , the most abundant phosphoinositide in cellular membranes, probably via interaction of its basic residues with lipid head groups [ 7 ]. Hippocalcin, a 22 kDa protein comprising 193 amino acids ( Figure 1 A), is highly expressed in the principal cells of the hippocampus...
Articles
Biochem Soc Trans (2009) 37 (6): 1419–1422.
Published: 19 November 2009
...Ann Swijsen; Govert Hoogland; Jean-Michel Rigo Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work...
Articles
Biochem Soc Trans (2008) 36 (6): 1267–1271.
Published: 19 November 2008
... georg001@umn.edu 3 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 brain development fetal iron deficiency hippocampus iron memory Iron is a ubiquitous metal that is essential for the function of all mammalian cells and yet also presents...
Articles
Biochem Soc Trans (2007) 35 (5): 1219–1223.
Published: 25 October 2007
... support to therapeutic trials of drugs antagonizing synaptic plasticity-disrupting actions of Aβ oligomers in preclinical AD. The involvement of TNFα in mediating the inhibition of LTP in the hippocampus by soluble Aβ complements the recent reports of Aβ-induced TNFα-dependent delayed impairment...
Articles
Biochem Soc Trans (2006) 34 (5): 949–951.
Published: 25 October 2006
... this regulation of neuronal kainate receptor function. 1 email Jack.Mellor@bristol.ac.uk 27 6 2006 © 2006 The Biochemical Society 2006 glutamate receptor hippocampus kainate receptor perirhinal cortex somatosensory cortex synaptic plasticity AMPA α-amino-3-hydroxy-5...
Articles
Biochem Soc Trans (2006) 34 (4): 600–604.
Published: 21 July 2006
... 3 2006 © 2006 The Biochemical Society 2006 brain-derived neurotrophic factor hippocampus long-term potentiation neurotrophin protein synthesis synaptic plasticity The function of the neurotrophin family of secretory peptides, including nerve growth factor, BDNF (brain...
Articles
Biochem Soc Trans (2005) 33 (5): 1029–1032.
Published: 26 October 2005
...-hypothalamic brain regions, including hippocampus, brain stem and cerebellum. Moreover, evidence is accumulating that leptin has other neuronal functions that are unrelated to its effects on energy homeostasis. Indeed a role for leptin in neuronal development has been suggested as leptin-deficient rodents...
Articles
Biochem Soc Trans (2005) 33 (6): 1299–1302.
Published: 26 October 2005
...R.A. McKinney The vast majority of excitatory connections in the hippocampus are made on dendritic spines. Both dendritic spines and molecules within the membrane are able to move, but the physiological role of these movements is unclear. In the developing brain, spines show highly dynamic...
Articles
Biochem Soc Trans (2005) 33 (4): 563–567.
Published: 01 August 2005
...M.J. Rowan; I. Klyubin; Q. Wang; R. Anwyl AD (Alzheimer's disease) is characterized by a progressive and devastating mental decline that is usually presaged by impairment of a form of memory dependent on medial temporal lobe structures, including the hippocampus. The severity of clinical dementia...
Articles
Biochem Soc Trans (2005) 33 (4): 573–577.
Published: 01 August 2005
... Society 2005 age hippocampus inflammation interleukin-10 (IL-10) IL-1β microglial activation Cognitive deficits in aged rats, particularly deficits in spatial information processing, have been consistently reported by several groups for many years; thus it has been demonstrated...
Articles
Biochem Soc Trans (2001) 29 (6): 736–741.
Published: 01 November 2001
... 5 2001 © 2001 Biochemical Society 2001 hippocampus neurotransmitter transporter protein trafficking synaptic function BIS, bisindolylmaleimide II BDNF, brain-derived neurotrophic factor GABA, γ-aminobutyric acid GAT, GABA transporter HBSS, Hepes-buffered saline solution...