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Keywords: high-throughput screening
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Articles
Biochem Soc Trans (2022) 50 (2): 713–721.
Published: 14 March 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biological networks genomics high-throughput screening Figure 1. Illustration of the experimental pipeline for discovery and analysis of genetic interactions in budding yeast. A principal goal...
Articles
Biochem Soc Trans (2021) 49 (3): 1337–1348.
Published: 22 June 2021
... targets high-throughput screening large-scale protein-fragment complementation assays protein–protein interactions proteome-wide analysis Protein–protein interactions (PPIs) constitute a complex cellular network and play a central role in nearly all biological processes, including DNA...
Articles
Biochem Soc Trans (2020) 48 (4): 1661–1673.
Published: 17 July 2020
... for high-throughput screenings. Correspondence: Atsuko Yamashita ( a_yama@okayama-u.ac.jp ) X-ray crystallography has been essential to the determination of the atomic structure of proteins for more than 60 years. Even with recent advances in cryo-electron microscopy (cryo-EM) [ 1...
Articles
Biochem Soc Trans (2018) 46 (1): 11–21.
Published: 01 December 2017
... screening. We also discuss the challenge to achieve a safe and targeted delivery of miRNA therapeutics in cardiovascular cells. cardiovascular disease gene therapy high-throughput screening microRNA This diverse range of biological effects has made them a tempting target for drug discovery...
Articles
Biochem Soc Trans (2016) 44 (6): 1617–1623.
Published: 02 December 2016
... ]. Correspondence: Heather Mortiboys ( h.mortiboys@sheffield.ac.uk ) 12 8 2016 25 8 2016 29 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 high-throughput screening leucine-rich repeat kinase mitochondria phenotypic...
Articles
Biochem Soc Trans (2012) 40 (5): 1158–1162.
Published: 19 September 2012
... sites and their regulation can be adapted to high-throughput-screening-amenable platforms. The present review describes the utilization of LRRK2 phosphorylation as indicators of enzyme inhibition, as well as how such assays can be used to deconvolute the pathways in which LRRK2 plays a role. 1...
Articles
Biochem Soc Trans (2010) 38 (4): 1046–1050.
Published: 26 July 2010
... potential for their use in regenerative therapy, the challenge remains to understand the basic biology of these remarkable cells, in order to differentiate them into any functional cell type. Given the scale of the task, high-throughput screening of agents and culture conditions offers one way to accelerate...
Articles
Biochem Soc Trans (2010) 38 (1): 132–136.
Published: 19 January 2010
.... 1 To whom correspondence should be addressed (email goldenberg@progenra.com ). 15 5 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 high-throughput screening homologous with E6-associated protein C-terminus (HECT) RING ubiquitin–protein ligase (E3...
Articles
Biochem Soc Trans (2007) 35 (3): 555–558.
Published: 22 May 2007
... Factor X/Xa fluorescence polarization high-throughput screening A similar high association rate constant was also observed for the Xase inhibitor, TFPI [ 5 ]. These very high association rate constants are mainly due to the effect of phospholipids co-localizing the reactants over a two...
Articles
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
... (1988) J. Biol. Chem. 263 , 8177–8182], an example where binding does not involve a secondary structural change. Synchrotron radiation CD spectroscopy offers significant enhancements with respect to conventional CD spectroscopy, which will enable its usage for high-throughput screening and as a tool...
Articles
Biochem Soc Trans (2002) 30 (4): 785.
Published: 01 August 2002
...A. Clark; S. Howell 1 To whom correspondence should be addressed(e-mail a.clark@organon.co.uk ) 9 4 2002 © 2002 Biochemical Society 2002 high-throughput screening ion channel nuclear receptor HTS, high-throughput screening High-Throughput Screening: The Way...
Articles
Biochem Soc Trans (2002) 30 (4): 786–788.
Published: 01 August 2002
...J. H. Connick The high-throughput screening platform implemented for drug discovery is driven by the therapeutic areas of interest. Therefore the speed and information derived is governed by these areas. Multiple technologies are needed to exploit this and it is also important to show reactivity...