... that correlates with the inability to form heterotetramers despite the presence of disulfide-linked heterodimers [ 42 ]. The heterodimerization of these transporters is strongly linked to their biogenesis. rBAT and b 0,+ AT are interdependent for trafficking from the ER to the plasma membrane [ 45 ]. Assembly...

... recording and nucleotide photolabelling on intact CFTR molecules, we relate opening and closing of the channel gates to ATP-mediated events in the NBDs. In particular, we demonstrate that two CFTR residues, predicted to lie on opposite sides of its anticipated NBD1–NBD2 heterodimer interface...