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Keywords: heparan sulphate 2-O-sulphotransferase
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Biochem Soc Trans (2003) 31 (2): 337–339.
Published: 01 April 2003
... of the gene encoding heparan sulphate 2-O-sulphotransferase die perinatally, due to the complete absence of kidneys. Similar phenotypes arise from targeted disruption of the genes encoding either GDNF, or its receptors, GFRα1 and c-Ret. It may therefore be proposed that GDNF normally binds to 2-O-sulphate...