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Keywords: heparan sulfate
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Biochem Soc Trans (2018) 46 (4): 789–796.
Published: 22 June 2018
... lesions to a fatal visceral infection. There is no single safe and effective approach to treat these diseases and resistance to current anti-leishmanial drugs is emerging. New drug targets need to be identified and validated to generate novel treatments. Host heparan sulfates (HSs) are abundant...
Biochem Soc Trans (2014) 42 (6): 1643–1646.
Published: 17 November 2014
...Giulia De Rossi; James R. Whiteford Syndecans are multifunctional heparan sulfate proteoglycans (HSPGs) with roles in cell adhesion, migration, receptor trafficking and growth-factor interactions and signalling. Studies using syndecan null animals have revealed limited roles for syndecans during...
Biochem Soc Trans (2014) 42 (6): 1596–1600.
Published: 17 November 2014
..., manifest an obligate dependence on heparan sulfate (HS) for their biological activity. This mandatory requirement of angiogenic cytokines for HS identifies HS as a potential target for novel anti-angiogenic therapy. Targeting multiple angiogenic cytokines with HS mimetics may represent an opportunity...
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
... to function co-operatively. HS (heparan sulfate) is a highly sulfated linear polysaccharide that resides at the pericellular cell–matrix interface where it dictates the binding and activity of a large number of proteins, including growth factors and morphogens such as members of the FGF (fibroblast growth...
Biochem Soc Trans (2011) 39 (1): 383–387.
Published: 19 January 2011
...Raymond A.A. Smith; Kate Meade; Claire E. Pickford; Rebecca J. Holley; Catherine L.R. Merry ES (embryonic stem) cell differentiation is dependent on the presence of HS (heparan sulfate). We have demonstrated that, during differentiation, the evolution of specific cell lineages is associated...
Biochem Soc Trans (2010) 38 (5): 1329–1332.
Published: 24 September 2010
... To whom correspondence should be addressed (email Barbara.Mulloy@nibsc.hpa.org.uk ). 4 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 glycobiology glycosaminoglycan (GAG) heparan sulfate lipopolysaccharide (LPS) O-linked β- N -acetylglucosamine (O-GlcNAc...
Biochem Soc Trans (2010) 38 (5): 1356–1360.
Published: 24 September 2010
...Jeremy E. Turnbull HSs (heparan sulfates) are a complex family of cell-surface and matrix polysaccharides that have diverse biological functions, underpinned by structurally diverse patterns of backbone chain modification, especially by sulfate groups. These variant structures represent a molecular...
Biochem Soc Trans (2008) 36 (2): 251–256.
Published: 20 March 2008
... exert their effects by activating receptors of the Robo (Roundabout) family, which resemble cell adhesion molecules in their ectodomains and have large, mainly unstructured cytosolic domains. HS (heparan sulfate) is required for Slit–Robo signalling. The hallmark of Slit proteins is a tandem of four LRR...