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Keywords: helicase
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Articles
Biochem Soc Trans (2018) 46 (1): 77–95.
Published: 22 December 2017
...Katrina N. Estep; Robert M. Brosh, Jr Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations in genes encoding DNA helicases of the RecQ and iron–sulfur (Fe–S) helicase families are linked to hereditary disorders characterized by chromosomal instabilities...
Articles
Biochem Soc Trans (2017) 45 (6): 1313–1321.
Published: 17 November 2017
... transitions are frequently promoted by RNA chaperone proteins, notably by superfamily 2 (SF2) RNA helicase proteins. The two largest families of SF2 helicases, DEAD-box and DEAH-box proteins, share evolutionarily conserved helicase cores, but unwind RNA helices through distinct mechanisms. Recent studies have...
Articles
Biochem Soc Trans (2017) 45 (5): 1173–1182.
Published: 22 September 2017
... of their function, efficient and controlled formation and unwinding are very important, because ‘mis’-regulated G-quadruplex structures are detrimental for a given process, causing genome instability and diseases. Several helicases have been shown to target and regulate specific G-quadruplex structures. This mini...
Articles
Biochem Soc Trans (2017) 45 (5): 1159–1171.
Published: 12 September 2017
...Alicia K. Byrd; Kevin D. Raney Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial DNA in eukaryotes. Saccharomyces cerevisiae Pif1 is involved in replication through barriers to replication, such as G-quadruplexes and protein blocks, and reduces genetic...
Articles
Biochem Soc Trans (2014) 42 (1): 166–172.
Published: 23 January 2014
...Wei-Ting Lu; Anna Wilczynska; Ewan Smith; Martin Bushell The eIF4A (eukaryotic initiation factor 4A) proteins belong to the extensive DEAD-box RNA helicase family, the members of which are involved in many aspects of RNA metabolism by virtue of their RNA-binding capacity and ATPase activity. Three...
Articles
Biochem Soc Trans (2011) 39 (2): 589–594.
Published: 22 March 2011
...Mark D. Szczelkun To cleave DNA, the Type III RM (restriction–modification) enzymes must communicate the relative orientation of two recognition sequences, which may be separated by many thousands of base pairs. This long-range interaction requires ATP hydrolysis by a helicase domain, and both...
Articles
Biochem Soc Trans (2010) 38 (2): 381–383.
Published: 22 March 2010
... of remarkable enzymes has evolved, which includes translocases, polymerases/replicases, helicases, nucleases, topoisomerases, transposases, recombinases, repair enzymes and ribosomes. An understanding of how these enzymes function is essential if we are to have a clear view of the molecular biology of the cell...
Articles
Biochem Soc Trans (2010) 38 (2): 404–409.
Published: 22 March 2010
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. ATPase DNA sliding helicase mismatch repair molecular switch restriction–modification The RM (restriction–modification...
Articles
Biochem Soc Trans (2009) 37 (3): 547–551.
Published: 20 May 2009
...Malcolm F. White The XPD (xeroderma pigmentosum complementation group D) helicase family comprises a number of superfamily 2 DNA helicases with members found in all three domains of life. The founding member, the XPD helicase, is conserved in archaea and eukaryotes, whereas the closest homologue...
Articles
Biochem Soc Trans (2009) 37 (1): 69–73.
Published: 20 January 2009
...Giuseppe Perugino; Anna Valenti; Anna D'Amaro; Mosè Rossi; Maria Ciaramella Reverse gyrase is a DNA topoisomerase that is peculiar in many aspects: it has the unique ability to introduce positive supercoils into DNA molecules; it comprises a type IA topoisomerase fused to a helicase-like domain...
Articles
Biochem Soc Trans (2009) 37 (1): 7–11.
Published: 20 January 2009
...Nozomi Sakakibara; Lori M. Kelman; Zvi Kelman In order for any organism to replicate its DNA, a helicase must unwind the duplex DNA in front of the replication fork. In archaea, the replicative helicase is the MCM (minichromosome maintenance) helicase. Although much is known about the biochemical...
Articles
Biochem Soc Trans (2009) 37 (1): 74–78.
Published: 20 January 2009
...Isabel L. Woodman; Edward L. Bolt Hel308 is an SF2 (superfamily 2) helicase with clear homologues in metazoans and archaea, but not in fungi or bacteria. Evidence from biochemistry and genetics implicates Hel308 in remodelling compromised replication forks. In the last 4 years, significant advances...
Articles
Biochem Soc Trans (2009) 37 (1): 83–87.
Published: 20 January 2009
... exosome helicase polyadenylation RNA degradation Figure 2 Displaced localization of active sites from archaea to eukaryotes Black stars indicate the active sites that changed from phosphate-dependent RNase and polymerase activity within the processing chamber (green) to hydrolytic RNase...
Articles
Biochem Soc Trans (2008) 36 (1): 136–140.
Published: 22 January 2008
...Alessandro Costa; Silvia Onesti The MCM2–MCM7 (minichromosome maintenance 2–7) complex is involved both in the initiation and the elongation step of eukaryotic DNA replication and is believed to be the replicative helicase. Whereas the mechanism of DNA unwinding at the replication fork has been...
Articles
Biochem Soc Trans (2005) 33 (6): 1471–1473.
Published: 26 October 2005
...E.L. Bolt Overcoming DNA replication fork blocks is essential for completing genome duplication and cell division. Archaea and eukaryotes drive replication using essentially the same protein machinery. Archaea may be a valuable resource for identifying new helicase components at advancing forks...
Articles
Biochem Soc Trans (2005) 33 (6): 1474–1478.
Published: 26 October 2005
...R.L. Eoff; K.D. Raney Helicases are molecular-motor enzymes that manipulate DNA or RNA during replication, repair, recombination, transcription, translation and processing of nucleic acids. The mechanisms for helicase activity have been studied intensely over the past decade. Recent advances in our...
Articles
Biochem Soc Trans (2004) 32 (6): 957–958.
Published: 26 October 2004
...H.W. Mankouri; I.D. Hickson RecQ helicases are evolutionarily conserved enzymes required for the maintenance of genome stability. Mutations in three of the five known human RecQ helicase genes cause distinct clinical disorders that are characterized by genome instability and cancer predisposition...
Articles
Biochem Soc Trans (2003) 31 (3): 703–705.
Published: 01 June 2003
... remote from replication origins. These functions are crucial to ensuring that genomes are transmitted successfully into subsequent generations of cells. Enzymes of HR have been unearthed in all three domains of life: bacteria, Archaea and eukarya. Helicases that specifically unwind branched DNA molecules...