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Keywords: heart failureClose
Biochem Soc Trans (2022) 50 (1): 439–446.
Published: 07 January 2022
... BY) . chronic kidney disease fibroblast growth factors heart failure hypertension phosphate small molecules Plasma phosphate (P i ) is tightly controlled in the range from 0.9 to 1.45 mmol L −1 in healthy adults [ 1 ], and requires a concerted interplay between intestinal uptake, storage/release...
Biochem Soc Trans (2020) 48 (6): 2483–2493.
Published: 01 December 2020
... failure and a major cause of morbidity and mortality worldwide with no effective treatment. Single-cell RNA-sequencing (scRNA-seq) offers a promising new platform to identify new cellular and molecular protagonists that may drive cardiac fibrosis and development of heart failure. This review...
Biochem Soc Trans (2020) 48 (5): 1905–1916.
Published: 14 October 2020
... participate in diverse physiological processes. In this review, we summarize the current knowledge in corin biosynthesis and post-translational modifications. We also discuss tissue-specific corin expression and function in physiology and disease. corin heart failure hypertension protease domains...
Biochem Soc Trans (2016) 44 (5): 1549–1560.
Published: 19 October 2016
...Lisha Ma Chronic heart failure is a common consequence of various heart diseases. Mechanical force is known to play a key role in heart failure development through regulating cardiomyocyte hypertrophy. In order to understand the complex disease mechanism, this article discussed a multi-disciplinary...
Biochem Soc Trans (2016) 44 (1): 25–34.
Published: 09 February 2016
... enhanced in polyP-depleted cells demonstrating that polyP protects cardiac myocytes against enhanced ROS formation. Furthermore, polyP concentration was dynamically changed during activation of the mitochondrial respiratory chain and stress conditions such as ischaemia/reperfusion (I/R) and heart failure...
Biochem Soc Trans (2014) 42 (2): 257–264.
Published: 20 March 2014
...-coupled receptor (GPCR) heart failure phosphodiesterase cAMP is an ubiquitous second messenger that plays a critical role in a multitude of biological functions [ 1 ]. It is one of the most important second messengers in the heart, regulating many physiological processes, such as cardiac...
Biochem Soc Trans (2012) 40 (1): 51–57.
Published: 19 January 2012
... 2012 Biochemical Society 2012 cAMP exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor guanine-nucleotide-exchange factor heart failure protein kinase A (PKA) cAMP is a universal second messenger which is produced from ATP by adenylate cyclase upon...
Biochem Soc Trans (2012) 40 (1): 11–14.
Published: 19 January 2012
...Alessandra Stangherlin; Manuela Zaccolo cAMP and cGMP signalling pathways are common targets in the pharmacological treatment of heart failure, and often drugs that modulate the level of these second messengers are simultaneously administered to patients. cGMP can potentially affect cAMP levels...
Biochem Soc Trans (2011) 39 (3): 781–787.
Published: 20 May 2011
... and affinity for Ca 2+ ions to the physiological demand of the heart. Dysregulation of the SERCA2a activity entails poor cardiomyocyte contractility, resulting in heart failure. Conversely, improving cardiac SERCA2a activity, e.g. by boosting its expression level or by increasing its affinity for Ca 2...
Biochem Soc Trans (2006) 34 (4): 502–503.
Published: 21 July 2006
... impact on cardiac reactions to mechanical stress: mice lacking PI3Kγ show increased mortality to aortic constriction accompanied by cardiomyocyte necrosis and heart failure [ 5 ]. Interestingly, these responses appeared to be linked to cAMP elevation, caused by the lack of PI3Kγ, as cardiac damage...
Biochem Soc Trans (2005) 33 (6): 1337–1340.
Published: 26 October 2005
... demonstrated that activation of the cAMP/protein kinase A pathway caused by the cardiac-specific overexpression of β-adrenergic receptors or G s α exacerbated heart failure [ 9 , 10 ], indicating that chronic stimulation of this pathway reduces cardiac function. In contrast, transgenic mice with cardiac...