... governing fibroblast activation. A better understanding of the molecular mechanisms that trigger and sustain the fibrotic process in heart disease has the potential to accelerate the development of therapies that specifically target the cardiac activated fibroblasts, which are at the moment unavailable...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 caveolae caveolin heart disease metabolism mitochondria Mitochondrial dynamics rely on co-ordinated control of mitochondrial biogenesis by balancing fusion, which is the mixing of healthy...

... from states of rest to activity. It is therefore not surprising that any factors that contribute to a loss of rhythm or contractility give rise to pathological consequences. Indeed, heart disease is a significant cause of mortality, being responsible, in 2004, for 137700 deaths in the U.K., equating...

... (GPCR) heart disease hypertrophy phosphoinositide 3-kinase γ (PI3Kγ) Abbreviations used: β-AR, β-adrenergic receptor; GPCR, G-protein-coupled receptor; PAF, platelet-activating factor; PI3K, phosphoinositide 3-kinase; PKB, protein kinase B; PTEN, phosphatase and tensin homologue deleted...

...(a) CHD, coronary heart disease Lp(a). lipoprotein(a) WOSCOPS, Wed of Scotland Coronary Prevention Study Lipoprotein(a) : the Really Bad Cholesterol? Use of the West of Scotland Coronary Prevention Study bio-bank to provide new insights into the control of plasma lipoprotein(a) concentrations...