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Keywords: heart
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Articles
Biochem Soc Trans (2015) 43 (3): 476–481.
Published: 01 June 2015
...Tânia Martins-Marques; Steve Catarino; Carla Marques; Paulo Pereira; Henrique Girão The main function of the heart is to pump blood to the different parts of the organism, a task that is efficiently accomplished through proper electric and metabolic coupling between cardiac cells, ensured by gap...
Articles
Biochem Soc Trans (2013) 41 (1): 95–100.
Published: 29 January 2013
...Jacqueline Howie; Lindsay B. Tulloch; Michael J. Shattock; William Fuller The Na + /K + -ATPase (Na + pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na + gradient established by the pump is essential for all aspects of cardiac function, and appropriate...
Articles
Biochem Soc Trans (2012) 40 (2): 297–309.
Published: 21 March 2012
... Alzheimer's disease bipolar disorder calcium heart inositol schizophrenia Calcium (Ca 2+ ) is a highly versatile intracellular signal capable of regulating many different processes [ 1 ]. To achieve this versatility, the signalling system operates in many different modes, thus enabling...
Articles
Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
... to breakdown rather than synthesize ATP and, if unrestrained, leads to necrotic cell death. The MPTP is opened in response to Ca 2+ overload, especially when accompanied by oxidative stress, elevated phosphate concentration and adenine nucleotide depletion. These conditions are experienced by the heart...
Articles
Biochem Soc Trans (2008) 36 (6): 1335–1338.
Published: 19 November 2008
... into the pathogenesis of this disorder, particularly that relating to the heart phenotype. AD-EDMD is more common than X-EDMD and is often more severe, with earlier onset, even in very early childhood. Both forms of EDMD are similar in that they each present with muscle weakness and early contractures of the elbow...
Articles
Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
... long QT syndrome RWS Romano–Ward syndrome This work was supported by the British Heart Foundation. References 1 Wang Q. Curran M.E. Splawski I. Burn T.C. Millholland J.M. VanRaay T.J. Shen J. Timothy K.W. Vincent G.M. de Jager T. Nat...
Articles
Biochem Soc Trans (2007) 35 (5): 927–930.
Published: 25 October 2007
...; of particular interest in cardiac physiology is the modulation of nNOS (neuronal nitric oxide synthase) by isoform 4b of PMCA. In the present paper, we will discuss recent advances that support a key role for PMCA4 in modulating the nitric oxide signalling pathway in the heart. A number of PDZ domain...
Articles
Biochem Soc Trans (2006) 34 (4): 489–491.
Published: 21 July 2006
...B. Lygren; K. Taskén Co-ordinated myocyte handling of calcium is essential for efficient excitation–contraction coupling in the heart. The calcium cycling activity can be modulated by adrenergic stimulation and subsequent phosphorylation. Important functional consequences of phosphorylation include...
Articles
Biochem Soc Trans (2006) 34 (2): 232–237.
Published: 20 March 2006
... cell death of the heart and brain that occurs during reperfusion after a long period of ischaemia. Such reperfusion injury is a major problem during cardiac surgery and in the treatment of coronary thrombosis and stroke. Prevention of MPTP opening either directly, using agents such as cyclosporin...
Articles
Biochem Soc Trans (2005) 33 (3): 539–542.
Published: 01 June 2005
... systems. I use models of the heart to demonstrate that we can now go all the way from individual genetic information (on mutations, for example) to exploring the consequences at a whole-organ level. An important strength of models based on reconstructing the functional properties of proteins...
Articles
Biochem Soc Trans (2004) 32 (5): 797–798.
Published: 26 October 2004
... indicate that plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development. β-catenin desmosomes heart plakoglobin zebrafish Cell adhesion is important in many cellular processes including organ development. In vertebrates, cell...
Articles
Biochem Soc Trans (2004) 32 (6): 1021–1024.
Published: 26 October 2004
... of the aroused condition and heart rates are as low as 3–10 beats/min, compared with 200–300 beats/min when the animal is active. This seasonal adaptation requires a metabolic shift away from the oxidation of carbohydrates and towards the combustion of stored fatty acids as the primary source of energy. A key...
Articles
Biochem Soc Trans (2001) 29 (2): 245–249.
Published: 01 May 2001
...S. Eaton; K. Fukumoto; N. Paladio Duran; A. Pierro; L. Spitz; P. A. Quant; K. Bartlett Carnitine palmitoyltransferase I is assumed to be rate limiting for β-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit β...
Articles
Biochem Soc Trans (2001) 29 (2): 325–330.
Published: 01 May 2001
.... Long-chain fatty acids (LCFA) are normally not available as an energy substrate for the fetal heart; however, when LCFA are supplied artificially in near-term fetal lambs, they are readily oxidized. Hence the myocardium has no limitation to its ability to use LCFA before birth. After birth, lactate...
Articles
Biochem Soc Trans (2001) 29 (2): 272–278.
Published: 01 May 2001
...-mail m.c.sugden@qmw.ac.uk ) 13 11 2000 © 2001 Biochemical Society 2001 heart liver muscle peroxisome-proliferator-activated receptor α pyruvate dehydrogenase pyruvate dehydrogenase kinase CPT, carnitine palmitoyltransferase FA, fatty acid PDC, pyruvate dehydrogenase complex PDK...