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Keywords: hamartomas
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Biochem Soc Trans (2003) 31 (3): 579–583.
Published: 01 June 2003
...V. Ramesh Tuberous sclerosis complex (TSC), an autosomal dominant disease caused by mutations in either TSC1 or TSC2 , is characterized by the development of hamartomas in a variety of organs. Concordant with the tumour-suppressor model, loss of heterozygosity (LOH) is known to occur...