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Keywords: haemogenic endothelium
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Biochem Soc Trans (2022) 50 (2): 703–712.
Published: 14 March 2022
... population, the haemogenic endothelium (HE). Signalling by the Transforming Growth Factor β (TGFβ) pathway is key to regulate haematopoiesis in the adult bone marrow, but evidence for a role in the formation of HSPCs has only recently started to emerge. In this review, we examine recent work in various model...
Biochem Soc Trans (2019) 47 (2): 591–601.
Published: 22 March 2019
... for definitive blood is not new. Histological observations made already 100 years ago proposed the existence of haemogenic endothelium [ 20 – 22 ]; however, experimental support came much later, initially in birds, but then also in mice. Using the avian system, which allows ex vivo manipulations, in this case...