...Lubna Freihat; Victor Muleya; David T. Manallack; Janet I. Wheeler; Helen R. Irving Over 30 receptor-like kinases contain a guanylate cyclase (GC) catalytic centre embedded within the C-terminal region of their kinase domain in the model plant Arabidopsis . A number of the kinase GCs contain both...

...Opher Gileadi Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery...

... 2007 Biochemical Society 2007 carbon monoxide-releasing molecule (CO-RM) guanylate cyclase haem oxygenase inflammation ischaemia vasodilatation Figure 1 Chemical structure of lipid-soluble and water-soluble CORMs The chemical structures of lipid-soluble (CORM-1 and CORM-2...

.... It contains a 5-coordinate (5c) His-ligated haem that shares spectroscopic and ligand-binding properties with the haem group in the sensory domain of soluble guanylate cyclase (sGC). The latter is an extremely important enzyme involved in the control of vasodilation and blood clotting. Curiously, the enzyme...

...-transduction pathway interferes with the octadecanoid cascade, probably due to increased salicylic acid levels, resulting in an inhibition of the typical jasmonic acid-induced volatile profile. 1 E-mail engelberth@ice.mpgde 26 6 2000 © 2000 Biochemical Society 2000 guanylate cyclase...