... endothelial barrier function exchange protein directly activated by cAMP (Epac) guanine-nucleotide-exchange factor (GEF) protein kinase A (PKA) vascular smooth muscle vasculature vasodilatation The second messenger cAMP controls a range of vascular processes, including endothelial barrier...

... Biochemical Society 2014 Cdc42 cytoskeleton GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) morphogenesis polarized growth secretion Fission yeast ( Schizosaccharomyces pombe ) has proven to be an excellent model organism to study cell morphogenesis. New cells...

... To whom correspondence should be addressed (email m.mccaffrey@ucc.ie ). 14 8 2012 © 2012 The Authors Journal 2012 disease GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) G-protein GTPase Rab YPT The Ras superfamily is a large grouping of monomeric...

...) guanine-nucleotide-dissociation inhibitor (GDI) Golgi complex GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) Rab GTPase How are Rab GTPases delivered to membranes? Rabs exist in the cytoplasm as 1:1 complexes with GDIs (guanine-nucleotide-dissociation inhibitors) [ 1...

...-exchange factor (GEF) Rab Rab membrane receptor vesicular trafficking The Rab family of small Ras-like G-proteins, consisting of 11 members in yeast and more than 60 in humans, are key regulators of intracellular vesicular trafficking in eukaryotic cells (for a recent review of Rab proteins, see...

... 2012 GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) GTPase kinase leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease PD (Parkinson's disease) is recognized as the second most common neurodegenerative disorder after Alzheimer's disease, affecting up to 1...

... correspondence should be addressed (email boris.kholodenko@ucd.ie ). 10 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gradient pattern GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) phosphorylation wave signalling In the middle...

... The Authors Journal compilation © 2008 Biochemical Society 2008 childhood ataxia with central nervous system hypomyelination (CACH) eukaryotic initiation factor 2B (eIF2B) G-protein guanine-nucleotide-exchange factor (GEF) leukoencephalopathy with vanishing white matter (VWM) translation initiation...