... of the polarity pathways, analogies between fission yeast and other model systems can be useful to decipher how cells can actively define their shape by polarized growth. Cdc42 cytoskeleton GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) morphogenesis polarized growth secretion...

... endothelial barrier function exchange protein directly activated by cAMP (Epac) guanine-nucleotide-exchange factor (GEF) protein kinase A (PKA) vascular smooth muscle vasculature vasodilatation The second messenger cAMP controls a range of vascular processes, including endothelial barrier...

...-exchange factor (GEF) Rab Rab membrane receptor vesicular trafficking The Rab family of small Ras-like G-proteins, consisting of 11 members in yeast and more than 60 in humans, are key regulators of intracellular vesicular trafficking in eukaryotic cells (for a recent review of Rab proteins, see...

... be important in defining competing trafficking events involving different Rab proteins. 1 To whom correspondence should be addressed (email m.mccaffrey@ucc.ie ). 14 8 2012 © 2012 The Authors Journal 2012 disease GTPase-activating protein (GAP) guanine-nucleotide-exchange factor...

...) guanine-nucleotide-dissociation inhibitor (GDI) Golgi complex GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) Rab GTPase Highlights of the new ‘cisternal progenitor model’ are be summarized in this section. The Golgi comprises a series of flattened cisterna that link...

... on LRRK2's kinase activity, the present review focuses on the function of LRRK2's GTPase activity in LRRK2 physiology and pathophysiology. © The Authors Journal compilation © 2012 Biochemical Society 2012 GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) GTPase kinase...

... correspondence should be addressed (email boris.kholodenko@ucd.ie ). 10 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gradient pattern GTPase-activating protein (GAP) guanine-nucleotide-exchange factor (GEF) phosphorylation wave signalling In the middle...

... The Authors Journal compilation © 2008 Biochemical Society 2008 childhood ataxia with central nervous system hypomyelination (CACH) eukaryotic initiation factor 2B (eIF2B) G-protein guanine-nucleotide-exchange factor (GEF) leukoencephalopathy with vanishing white matter (VWM) translation initiation...