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Keywords: guanine nucleotide exchange factor
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Biochem Soc Trans (2020) 48 (6): 2703–2719.
Published: 16 November 2020
...Joe Maltas; Hannah Reed; Andrew Porter; Angeliki Malliri The Tiam family proteins — Tiam1 and Tiam2/STEF — are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Tiam GEFs regulate cellular migration, proliferation...
Biochem Soc Trans (2003) 31 (5): 966–969.
Published: 01 October 2003
.... Whether Ras is in its active GTP-bound, or inactive GDP-bound, form is determined by the activity of guanine nucleotide exchange factors (GEFs) and GTPase-activating protein (GAPs). Calcium-regulated GEFs and GAPs have been identified, some with an exquisite sensitivity to [Ca 2+ ] i , implicating...