...Nishanth Belugali Nataraj; Ilaria Marrocco; Yosef Yarden Cancer is initiated largely by specific cohorts of genetic aberrations, which are generated by mutagens and often mimic active growth factor receptors, or downstream effectors. Once initiated cells outgrow and attract blood vessels, a multi...

... such as pattern formation and neurogenesis. Torso-like (Tsl) from the fruit fly Drosophila , for example, functions to localise the activity of a growth factor for patterning its embryonic termini. It remains unclear whether these developmental proteins employ an attenuated form of the classical MACPF lytic pore...

... The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cell migration extracellular matrix growth factors metastasis stroma tumor microenvironments Carcinomas are heterogeneous tissues composed of cancer cells and stromal cells, such as fibroblasts...

... biological phenomena, as important regulatory opportunities. 1 email matthew.freeman@path.ox.ac.uk 26 1 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cytokines growth factors intracellular transport rhomboids...

...A.L. Edinger Growth factors provide permission signals that allow mammalian cells to grow, proliferate and survive. One mechanism by which growth factors maintain this control is through the regulation of cell surface nutrient transporter expression. Following growth factor withdrawal, nutrient...