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Keywords: growth factor
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Articles
Biochem Soc Trans (2021) 49 (5): 1963–1973.
Published: 08 September 2021
...Matthew Ratcliff; Richard Xu Zhou; Lutz Jermutus; Marko Hyvönen Many growth factors and cytokines are produced as larger precursors, containing pro-domains, that require proteolytic processing to release the bioactive ligand. These pro-domains can be significantly larger than the mature domains...
Articles
Biochem Soc Trans (2017) 45 (1): 51–64.
Published: 15 February 2017
...-coding RNAs supports tumour progression is poorly understood. Here, we review new lines of evidence linking long and short types of non-coding RNAs to signalling pathways activated in the course of cancer progression by growth factors and by the tumour micro-environment. Resolving the new dimension...
Articles
Biochem Soc Trans (2017) 45 (1): 223–228.
Published: 15 February 2017
..., but not ALK6] and type II BMP receptors, activating SMAD 1/5/8 signaling and controlling the cell cycle pathway. Furthermore, the compound is capable of blocking transforming growth factor-β induced epithelial-to-mesenchymal transition (EMT) in primary tumor cells, a critical step for tumor progression...
Articles
Biochem Soc Trans (2013) 41 (4): 902–905.
Published: 18 July 2013
...Alejo Efeyan; David M. Sabatini Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its...
Articles
Biochem Soc Trans (2012) 40 (1): 26–30.
Published: 19 January 2012
... mini-review, we use a set of examples to illustrate the extensive interdependence between miRNAs and signalling networks. cancer growth factor microRNA (miRNA) network tyrosine kinase Signalling 2011: a Biochemical Society Centenary Celebration: A Biochemical Society Focused Meeting held...
Articles
Biochem Soc Trans (2011) 39 (6): 1628–1632.
Published: 21 November 2011
...Thomas Gustafsson Exercise-induced angiogenesis in skeletal muscle involves both non-sprouting and sprouting angiogenesis and results from the integrated responses of multiple systems and stimuli. VEGF-A (vascular endothelial growth factor A) levels are increased in exercised muscle and have been...
Articles
Biochem Soc Trans (2009) 37 (4): 717–721.
Published: 22 July 2009
...Andrew J. Moss; Shikha Sharma; Nicholas P.J. Brindle Growth factors provide key instructive cues for tissue formation and repair. However, many natural growth factors are limited in their usefulness for tissue engineering and regenerative applications by their poor retention at desired sites...
Articles
Biochem Soc Trans (2007) 35 (4): 698–700.
Published: 20 July 2007
... stromal cells) play a major role in supporting prostate cancer growth and survival in bone. Here, we examine factors shown to be secreted by BMSCs, such as IGFs (insulin-like growth factors) and IL-6 (interleukin 6), shown to promote prostate cancer cell proliferation and to potentially replace...
Articles
Biochem Soc Trans (2007) 35 (2): 229–230.
Published: 20 March 2007
... © 2007 The Biochemical Society 2007 growth factor phospholipase C (PLC) pleckstrin homology domain (PH domain) phosphoinositide 3-kinase (PI3K) Src homology 2 domain (SH2 domain) tyrosine phosphorylation PtdIns(4,5) P 2 is a minor phospholipid component of cell membrane (∼0.5...
Articles
Biochem Soc Trans (2007) 35 (2): 250–252.
Published: 20 March 2007
...M.A. Guthridge; A.F. Lopez Cytokines and growth factors exert multiple biological activities through their ability to engage and activate specific receptors displayed on the surface of cells. How these receptors are able to differentially (and sometimes independently) regulate cell survival...
Articles
Biochem Soc Trans (2006) 34 (6): 1079–1081.
Published: 25 October 2006
... of ribosome assembly. growth factor mammalian cell ribosomal RNA gene RNA polymerase I rRNA transcription elongation When so much emphasis is being placed on the role of protein coding genes, it is a sobering thought that a eukaryotic cell must provide on average ten ribosomes for every...
Articles
Biochem Soc Trans (2006) 34 (5): 833–836.
Published: 25 October 2006
... and movement. Five distinct groups of MAPKs have been characterized in mammals, the most extensively studied of which is the Ras/Raf/MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase]/ERK cascade. Numerous stimuli, including growth factors and phorbol esters, activate MEK/ERK signalling. How...
Articles
Biochem Soc Trans (2006) 34 (3): 454–455.
Published: 22 May 2006
...S. Kurup; A. Abramsson; J.P. Li; U. Lindahl; L. Kjellen; C. Betsholtz; H. Gerhardt; D. Spillmann HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability...
Articles
Biochem Soc Trans (2005) 33 (6): 1313–1315.
Published: 26 October 2005
...L. Veracini; M. Franco; A. Boureux; V. Simon; S. Roche; C. Benistant The cytoplasmic tyrosine kinases of the Src family (SFK) play important roles in cell responses induced by growth factors, including cell growth, survival and migration. Here, we review how SFK participate in PDGF (platelet...
Articles
Biochem Soc Trans (2004) 32 (5): 742–745.
Published: 26 October 2004
...K.M. Ferguson The members of the EGFR (epidermal growth factor receptor) family of RTKs (receptor tyrosine kinases), also known as the ErbB or HER family, have been implicated in many human cancers. Structural studies of the EGFR extracellular region (sEGFR) have led to the proposal of a novel...
Articles
Biochem Soc Trans (2003) 31 (6): 1441–1444.
Published: 01 December 2003
... of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 9 July 2003 © 2003 Biochemical Society 2003 apoptosis growth factor Mn superoxide dismutase Ras reactive oxygen species (ROS) senescence Abbreviations used: AP-1, activator protein-1; DPI...
Articles
Biochem Soc Trans (2003) 31 (2): 337–339.
Published: 01 April 2003
...C.C. Rider Glial cell line-derived growth factor (GDNF) is a cytokine of the transforming growth factor (TGF)-β family with potent neuroprotective activity. Clinical trials of recombinant GDNF in advanced Parkinson's disease are currently under way. It is known that mice homozygous for disruption...