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Keywords: ground stateClose
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1027–1032.
Published: 26 July 2010
.... Inhibition of GSK3 (glycogen synthase kinase 3) reinforces this effect. We review the effect of selective kinase inhibitors on pluripotent cells and consider how these effects are mediated. We propose that ES cells represent a ground state, meaning a basal proliferative state that is free of epigenetic...