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Keywords: glycosylation
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Articles
Biochem Soc Trans (2022) 50 (2): 1003–1012.
Published: 11 April 2022
...Daniel B. Williamson; Robert S. Haltiwanger O -glycosylation of Epidermal Growth Factor-like (EGF) repeats plays crucial roles in protein folding, trafficking and function. The Notch extracellular domain has been used as a model to study these mechanisms due to its many O- glycosylated EGF repeats...
Articles
Biochem Soc Trans (2021) 49 (6): 2891–2901.
Published: 16 November 2021
... deglycosylation glycosylation O -GlcNAc post translational modification protein engineering O- GlcNAc is a monosaccharide post-translational modification (PTM) installed on thousands of nucleocytoplasmic and mitochondrial proteins at multiple serine or threonine residues in eukaryotic cells [ 1...
Articles
Biochem Soc Trans (2021) 49 (2): 903–913.
Published: 16 April 2021
... not have a common core structure and are classified by the nature of the first monosaccharide residue that is linked to the protein. The most common type of cell surface O-glycosylation is mucin-type glycosylation, in which the first monosaccharide is an N -acetylgalactosamine (GalNAc) [ 6 ]. Other types...
Articles
Biochem Soc Trans (2021) 49 (2): 915–931.
Published: 11 March 2021
...Roberto Donini; Stuart M. Haslam; Cleo Kontoravdi Biotherapeutic glycoproteins have revolutionised the field of pharmaceuticals, with new discoveries and continuous improvements underpinning the rapid growth of this industry. N-glycosylation is a critical quality attribute of biotherapeutic...
Articles
Biochem Soc Trans (2021) 49 (2): 843–854.
Published: 11 March 2021
...Joana G. Rodrigues; Henrique O. Duarte; Celso A. Reis; Joana Gomes Aberrant cell surface glycosylation signatures are currently known to actively drive the neoplastic transformation of healthy cells. By disrupting the homeostatic functions of their protein carriers, cancer-associated glycans...
Articles
Biochem Soc Trans (2021) 49 (1): 161–186.
Published: 13 January 2021
... - and O -linked glycopeptides [ 22 ], studies published since 2018 are now routinely identifying and quantifying thousands of glycopeptides, some even beyond 10 000 and 20 000 intact glycopeptides [ 49 , 50 ]. glycopeptide glycoproteins glycoproteomics glycosylation LC-MS/MS mass spectrometry...
Articles
Biochem Soc Trans (2020) 48 (3): 891–900.
Published: 15 June 2020
... of glycosyltransferases within compartments of the Golgi apparatus may play a role in mitigating the glycan variability caused by enzyme promiscuity. biosynthesis glycosylation promiscuity During glycan synthesis, the acceptor substrates are complex oligosaccharides which potentially contain many sites to which...
Articles
Biochem Soc Trans (2020) 48 (3): 1287–1295.
Published: 08 June 2020
...-glycosylation pathways to virus replication and the drugs available to disrupt these pathways. In particular, we make a case for evaluation of the well-tolerated drugs miglitol, celgosivir and especially miglustat for the treatment of COVID-19. Correspondence: Ethan D. Goddard-Borger ( Goddard-Borger.E...
Articles
Biochem Soc Trans (2019) 47 (6): 1569–1579.
Published: 14 November 2019
... lectin receptors. These lectins may contribute to initial recognition of bacterial glycans, thus providing an early defence mechanism against bacterial infections, but they may also be exploited by bacteria to escape immune responses. In this review, we will first exemplify bacterial glycosylation...
Articles
Biochem Soc Trans (2018) 46 (3): 691–698.
Published: 21 May 2018
... 30 disulfide bonds and around a 100 N-linked glycosylation sites, and are functionally dependent on protease cleavage within the secretory system. The resulting mature structure adopts a compact fold with the vast majority of its surface obscured by a protective shield of glycans which can...
Articles
Biochem Soc Trans (2018) 46 (2): 343–350.
Published: 09 March 2018
...Maria C. Rodriguez Benavente; Pablo Argüeso Glycosylation is a major form of enzymatic modification of organic molecules responsible for multiple biological processes in an organism. The biosynthesis of glycans is controlled by a series of glycosyltransferases, glycosidases and glycan-modifying...
Articles
Biochem Soc Trans (2017) 45 (2): 389–399.
Published: 13 April 2017
... to infection and cancer [ 13 , 14 ]. Secreted mucins predominate in works describing the interaction of bacterial adhesins with human mucosa, but transmembrane mucin O -glycans can also serve as a target for bacterial adhesion [ 15 ]. adhesins gastrointestinal mucins glycosylation microbiota...
Articles
Biochem Soc Trans (2011) 39 (1): 388–392.
Published: 19 January 2011
...Eirikur Saeland; Yvette van Kooyk A common phenotypic change in cancer is a dramatic transformation of cellular glycosylation. Functional studies of particular tumour-associated oligosaccharides are difficult to interpret conclusively, but carbohydrate-binding proteins are likely to contribute...
Articles
Biochem Soc Trans (2011) 39 (1): 327–330.
Published: 19 January 2011
...Jayne E. Telford; Margaret A. Doherty; Tharmala Tharmalingam; Pauline M. Rudd Glycosylation modifications have been reported in a number of disease states and, as a result, there is significant focus on the discovery and development of glycan-based biomarkers. Glyco-biomarkers have the potential...
Articles
Biochem Soc Trans (2011) 39 (1): 336–339.
Published: 19 January 2011
...Jane E. Hewitt During the last 10 years it has become apparent that a significant subset of inherited muscular dystrophy is caused by errors in the glycosylation of α-dystroglycan. Many of these dystrophies are also associated with abnormalities of the central nervous system. Dystroglycan has...
Articles
Biochem Soc Trans (2011) 39 (1): 370–373.
Published: 19 January 2011
.... Aberrant glycosylation is a hallmark of malignancy and a well-studied class of β1,6-branched oligosaccharides is associated with malignant transformation of rodent and human cells, and poor prognosis in cancer patients. It is evident that increased β1,6 branching significantly contributes to the phenotype...
Articles
Biochem Soc Trans (2011) 39 (1): 399–405.
Published: 19 January 2011
... substitutions. What poses an enormous challenge for analytical processing is, at the same time, the basis for the fingerprint-like glycomic profiles of glycoconjugates and cells. What's more, the glycosylation machinery is sensitive to disease manifestations, earning glycan assembly a reputation as a promising...
Articles
Biochem Soc Trans (2010) 38 (5): 1374–1377.
Published: 24 September 2010
...Li Liu; Jayne E. Telford; Ana Knezevic; Pauline M. Rudd The development of glycoanalytical HPLC-based high-throughput technology has greatly enhanced the study of glycobiology, facilitating the discovery of disease-related solutions and providing an informative view of glycosylation and its...
Articles
Biochem Soc Trans (2010) 38 (5): 1307–1313.
Published: 24 September 2010
...Paul G. Hitchen; Katie Twigger; Esmeralda Valiente; Rebecca H. Langdon; Brendan W. Wren; Anne Dell With glycosylation now firmly established across both Archaeal and bacterial proteins, a wide array of glycan diversity has become evident from structural analysis and genomic data. These discoveries...
Articles
Biochem Soc Trans (2008) 36 (6): 1491–1496.
Published: 19 November 2008
... to ensure translation of sugar signals into an array of biological responses. This process of a lectin–carbohydrate rendezvous is likely to be intimately regulated. Analysing this interaction closely discerns six levels of affinity regulation. glycoprotein glycosylation inflammation lectin...
Articles
Biochem Soc Trans (2005) 33 (5): 1094–1095.
Published: 26 October 2005
... of PrP's N-glycans to the misfolding of the protein. However, despite the absence of spontaneous PrP misfolding in these models, all our glycosylation-deficient lines are susceptible to transmitted TSE and accumulate PrP Sc during the disease process. The lack of spontaneous formation of PrP Sc in our...
Articles
Biochem Soc Trans (2004) 32 (1): 33–36.
Published: 01 February 2004
... 2004 Alzheimer's disease amyloidogenesis cholesterol glycosylation lovastatin proteolysis β-secretase Abbreviations used: Aβ, β-amyloid; APP, Alzheimer's amyloid precursor protein; APPswe, Swedish mutant of APP; ASP-2, aspartic protease 2; FCS, fetal calf serum; Endo H...