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Keywords: glycolysis
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Biochem Soc Trans (2021) 49 (2): 715–726.
Published: 26 March 2021
... from being lowered; i.e. (I) the intracellular pH-buffering system and (II) the proton-transporting system from the intracellular space to the extracellular one. glycolysis insulin interstitial fluid pH mitochondria TCA cycle type 2 diabetes mellitus Metabolic disorders cause...
Biochem Soc Trans (2021) 49 (1): 313–325.
Published: 01 February 2021
... for their own energetic needs. Research over the past decade highlighted how manipulation of endothelial glycolysis can be used to control angiogenesis and microvascular permeability in diseases such as cancer. Finally, endothelial cells transport glucose to the cells of the blood vessel wall...
Biochem Soc Trans (2016) 44 (6): 1667–1673.
Published: 02 December 2016
... transcription factor and mTOR kinase, couple the activation of the translational machinery with glycolysis and fatty acid synthesis. Eukaryotic initiation factor 6 (eIF6) is a factor necessary for 60S ribosome maturation. eIF6 acts also as a cytoplasmic translation initiation factor, downstream of growth factor...
Biochem Soc Trans (2016) 44 (5): 1499–1505.
Published: 19 October 2016
... compared with normal cells, which oxidised glucose using mitochondria. It was therefore assumed that cancer cells were generating energy using glycolysis rather than mitochondrial oxidative phosphorylation, and that the mitochondria were dysfunctional. Advances in research techniques since then have shown...
Biochem Soc Trans (2015) 43 (4): 758–762.
Published: 03 August 2015
... of rapamcyin (mTOR) complex 1 (mTORC1) has been identified as a key metabolic regulator that promotes glycolytic metabolism in multiple immune cell subsets. Glycolysis is integrally linked to pro-inflammatory immune responses such that activated NK cells and effector T-cell subsets are reliant on sufficient...
Biochem Soc Trans (2014) 42 (6): 1756–1761.
Published: 17 November 2014
...Da-Woon Jung; Woong-Hee Kim; Darren R. Williams Glycolysis is an ancient biochemical pathway that breaks down glucose into pyruvate to produce ATP. The structural and catalytic properties of glycolytic enzymes are well-characterized. However, there is growing appreciation that these enzymes...
Biochem Soc Trans (2014) 42 (4): 985–988.
Published: 11 August 2014
..., possess the required catalytic capacities. An alternative scenario for the origin of metabolism involves chemical reactions that are based on environmental catalysts. Recently, we described a non-enzymatic glycolysis and pentose phosphate pathway-like reactions catalysed by metal ions [mainly Fe(II...
Biochem Soc Trans (2014) 42 (2): 413–418.
Published: 20 March 2014
... Dakin and Harold Ward Dudley in 1913. All three were leading extraordinary investigators in the pioneering years of biochemistry. Neuberg proposed glyoxalase as the pathway of mainstream glycolysis and Gustav Embden correctly discounted this, later confirmed by Otto Meyerhof. Albert Szent-Györgyi...
Biochem Soc Trans (2013) 41 (5): 1294–1297.
Published: 23 September 2013
...Rabia Ramzan; Petra Weber; Uwe Linne; Sebastian Vogt The main function of glycolysis and oxidative phosphorylation is to produce cellular energy in the form of ATP. In the present paper we propose a link between both of these energy-regulatory processes in the form of GAPDH (glyceraldehyde-3...
Biochem Soc Trans (2013) 41 (2): 681–686.
Published: 21 March 2013
.... In many cell systems, mTORC1 couples PI3K (phosphoinositide 3-kinase) and PKB (protein kinase B), also known as Akt, with the control of glucose uptake and glycolysis. However, this is not the case in activated CD8 + CTLs (cytotoxic T-lymphocytes) where PI3K/PKB signalling is dispensable for the elevated...
Biochem Soc Trans (2013) 41 (2): 664–669.
Published: 21 March 2013
...Danielle G. Smith; Roger G. Sturmey A key characteristic of cancer cells is the ability to switch from a predominantly oxidative metabolism to glycolysis and the production of lactate even when oxygen is plentiful. This metabolic switch, known as the Warburg effect, was first described in the 1920s...
Biochem Soc Trans (2011) 39 (1): 77–81.
Published: 19 January 2011
... ]), and functional genomics approaches, including transcriptomics, proteomics, comparative genomics, as well as a systems biology approach have been applied [ 5 – 7 ]. central carbohydrate metabolism crenarchaeon Entner–Doudoroff pathway glucose dehydrogenase glycolysis Sulfolobus solfataricus...
Biochem Soc Trans (2007) 35 (2): 305–310.
Published: 20 March 2007
...@molbiol.umu.se ). 29 9 2006 © 2007 The Biochemical Society 2007 glycolysis lymphomagenesis Myc nucleotide biogenesis polyamine The strength of using mouse models of cancer is that the importance of a gene can be determined both for the induction of tumorigenesis...
Biochem Soc Trans (2005) 33 (5): 945–948.
Published: 26 October 2005
...). These plants perform primary CO 2 fixation at night using the enzyme phosphoenolpyruvate carboxylase and exhibit a robust rhythm of CO 2 fixation under constant conditions. Transcriptomic analysis has revealed that many genes encoding enzymes in primary metabolic pathways such as glycolysis and starch...
Biochem Soc Trans (2004) 32 (2): 259–263.
Published: 01 April 2004
... Archaea crystal structure decamer fructose-1,6-bisphosphate aldolase (FBP aldolase) glycolysis triosephosphate isomerase (TIM) barrel evolution Abbreviations used: FBPA, fructose-1,6-bisphosphate aldolase; GAP, glyceraldehyde 3-phosphate; DHAP, dihydroxyacetone phosphate; FBP, fructose 1,6...
Biochem Soc Trans (2003) 31 (6): 1263–1266.
Published: 01 December 2003
... Society held at the University of Essex, Colchester, 2–4 July 2003 6 June 2003 © 2003 Biochemical Society 2003 aerobic metabolism computer simulation exercise glycolysis Abbreviations used: MLSS, maximal lactate steady state; BLC, blood lactate concentration. Exercise...
Biochem Soc Trans (2003) 31 (1): 213–215.
Published: 01 February 2003
... Protein Kinase, a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002 10 September 2002 Copyright 2003 Biochemical Society 2003 apoptosis glycolysis Pasteur Effect protein synthesis Abbreviations used: AMPK, AMP-activated...
Biochem Soc Trans (2002) 30 (2): 38–43.
Published: 01 April 2002
... glucose 6-P, glucose 6-phosphate glucose I-P, glucose 1-phosphate fructose I-P, fructose 1-phosphate fructose 6-P, fructose 6-phosphate compartmentation glycolysis intermediates Biochemical Society Transactions (2002) Volume 30, part 2 References I 2 3 4 5 6 7 8 9 10 I I I 2 13 14 15 16...