... 2021 25 2 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 glycolysis insulin interstitial fluid pH mitochondria TCA cycle type 2 diabetes mellitus Metabolic disorders cause various types of diseases including type 2...

... for their own energetic needs. Research over the past decade highlighted how manipulation of endothelial glycolysis can be used to control angiogenesis and microvascular permeability in diseases such as cancer. Finally, endothelial cells transport glucose to the cells of the blood vessel wall...

... transcription factor and mTOR kinase, couple the activation of the translational machinery with glycolysis and fatty acid synthesis. Eukaryotic initiation factor 6 (eIF6) is a factor necessary for 60S ribosome maturation. eIF6 acts also as a cytoplasmic translation initiation factor, downstream of growth factor...

... compared with normal cells, which oxidised glucose using mitochondria. It was therefore assumed that cancer cells were generating energy using glycolysis rather than mitochondrial oxidative phosphorylation, and that the mitochondria were dysfunctional. Advances in research techniques since then have shown...

... of rapamcyin (mTOR) complex 1 (mTORC1) has been identified as a key metabolic regulator that promotes glycolytic metabolism in multiple immune cell subsets. Glycolysis is integrally linked to pro-inflammatory immune responses such that activated NK cells and effector T-cell subsets are reliant on sufficient...

... 13211595 26 Rider M.H. Bertrand L. Vertommen D. Michels P.A. Rousseau G.G. Hue L. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis Biochem. J. 2004 381 561 579 10.1042/BJ20040752 15170386 27...

...Da-Woon Jung; Woong-Hee Kim; Darren R. Williams Glycolysis is an ancient biochemical pathway that breaks down glucose into pyruvate to produce ATP. The structural and catalytic properties of glycolytic enzymes are well-characterized. However, there is growing appreciation that these enzymes...

..., possess the required catalytic capacities. An alternative scenario for the origin of metabolism involves chemical reactions that are based on environmental catalysts. Recently, we described a non-enzymatic glycolysis and pentose phosphate pathway-like reactions catalysed by metal ions [mainly Fe(II...

... Dakin and Harold Ward Dudley in 1913. All three were leading extraordinary investigators in the pioneering years of biochemistry. Neuberg proposed glyoxalase as the pathway of mainstream glycolysis and Gustav Embden correctly discounted this, later confirmed by Otto Meyerhof. Albert Szent-Györgyi...

...Rabia Ramzan; Petra Weber; Uwe Linne; Sebastian Vogt The main function of glycolysis and oxidative phosphorylation is to produce cellular energy in the form of ATP. In the present paper we propose a link between both of these energy-regulatory processes in the form of GAPDH (glyceraldehyde-3...

.... In many cell systems, mTORC1 couples PI3K (phosphoinositide 3-kinase) and PKB (protein kinase B), also known as Akt, with the control of glucose uptake and glycolysis. However, this is not the case in activated CD8 + CTLs (cytotoxic T-lymphocytes) where PI3K/PKB signalling is dispensable for the elevated...

...Danielle G. Smith; Roger G. Sturmey A key characteristic of cancer cells is the ability to switch from a predominantly oxidative metabolism to glycolysis and the production of lactate even when oxygen is plentiful. This metabolic switch, known as the Warburg effect, was first described in the 1920s...

... glucose dehydrogenase glycolysis Sulfolobus solfataricus Sulfolobus Systems Biology (SulfoSYS) © The Authors Journal compilation © 2011 Biochemical Society 2011 15 8 2010 1 To whom correspondence should be addressed (email bettina.siebers@uni-due.de ). D -Galactose...

... attention, as they may be critical arbiters of Myc in cancer. Thus targeting metabolic enzymes encoded by Myc-target genes may provide a new means to treat cancer that have arisen in response to deregulated Myc oncogenes. 29 9 2006 © 2007 The Biochemical Society 2007 glycolysis...

...). These plants perform primary CO 2 fixation at night using the enzyme phosphoenolpyruvate carboxylase and exhibit a robust rhythm of CO 2 fixation under constant conditions. Transcriptomic analysis has revealed that many genes encoding enzymes in primary metabolic pathways such as glycolysis and starch...

... Archaea crystal structure decamer fructose-1,6-bisphosphate aldolase (FBP aldolase) glycolysis triosephosphate isomerase (TIM) barrel evolution Abbreviations used: FBPA, fructose-1,6-bisphosphate aldolase; GAP, glyceraldehyde 3-phosphate; DHAP, dihydroxyacetone phosphate; FBP, fructose 1,6...

... Society held at the University of Essex, Colchester, 2–4 July 2003 6 June 2003 © 2003 Biochemical Society 2003 aerobic metabolism computer simulation exercise glycolysis Abbreviations used: MLSS, maximal lactate steady state; BLC, blood lactate concentration. Exercise...

... Protein Kinase, a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002 10 September 2002 Copyright 2003 Biochemical Society 2003 apoptosis glycolysis Pasteur Effect protein synthesis Abbreviations used: AMPK, AMP-activated...

... glucose 6-P, glucose 6-phosphate glucose I-P, glucose 1-phosphate fructose I-P, fructose 1-phosphate fructose 6-P, fructose 6-phosphate compartmentation glycolysis intermediates Biochemical Society Transactions (2002) Volume 30, part 2 References I 2 3 4 5 6 7 8 9 10 I I I 2 13 14 15 16...