... extracellular matrix fibrillins glycobiology glycosylation LTBPs Addition of glucose or fucose to the hydroxyls of serine or threonine residues (i.e. O -linked) in Epidermal Growth Factor-like (EGF) repeats was discovered more than three decades ago. O- glucose was reported on EGF repeats of blood...

... glycobiology humanized mice immune checkpoint sialic acid Siglec transgenic mice Siglecs, or sialic acid-binding immunoglobulin-like lectins, make up an immunoglobulin superfamily of transmembrane receptors located predominantly on the surface of immune cells. These receptors bind to sialic acid...

... glycobiology mass spectrometry nmr spectroscopy norovirus Noroviruses belong to the family of Caliciviridae , non-enveloped viruses with a single-stranded positive-sense RNA. Phylogenetically noroviruses are segregated into ten established genogroups that are further subdivided into genotypes [ 1...

... making glycoproteins important diagnostic and prognostic biomarker candidates and therapeutic targets. Glycoproteomics, the study of glycans and their carrier proteins in a system-wide context, is becoming a powerful tool in glycobiology that enables the functional analysis of protein glycosylation...

... reporter chemoenzymatic labelling glycobiology glycosylation metabolic engineering Glycans play crucial roles in a diversity of cellular processes. For example, glycoproteins are essential mediators of cell–cell and cell–matrix interactions, they are involved in cell recognition and signalling...

... of the Biochemical Society 2019 glycan-binding proteins glycobiology glycomics microarrays shotgun glycomics The surfaces of all living cells comprises a heterogeneous assortment of macromolecules that provides an interface of cells with their aqueous environment. Glycans that comprise...

... by Portland Press Limited on behalf of the Biochemical Society 2018 glycobiology glycosylation immunogen vaccine virus The immense variation of the genome of HIV presents a considerable obstacle to the development of an effective, sterilizing vaccine. The failure of classical vaccination...

... BY) . calnexin drug discovery and design glucosidase glycobiology iminosugar Enveloped viruses have a membrane surrounding their capsid, which is composed of lipids derived from host membranes and viral glycoproteins. These viral glycoproteins are typically dependent upon the host endoplasmic...

... © 2016 Authors; published by Portland Press Limited 2016 biofuels conformational analysis drug design glycobiology glycosidase structural biology Glycans are found almost everywhere, and the enzymes that synthesize, modify and degrade these complex molecules are central to human...

...Barbara Mulloy; Anthony P. Corfield The glycans (carbonhydrates) form a diverse group of biomolecules which play active parts in most physiological processes. The field of structural glycobiology concerns the structures of the glycans themselves, the proteins which interact with them and the nature...