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Keywords: glutathione
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Articles
Biochem Soc Trans (2020) 48 (5): 2253–2259.
Published: 14 October 2020
... glutathione GPX4 lipid peroxidation Ferroptosis is a form of regulated cell death, which is unique, and defined by its requirement of iron-dependent lipid peroxidation [ 1 ]. Ferroptosis regulation is intertwined with an ever-growing array of metabolic processes, such as amino acid metabolism...
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Biochem Soc Trans (2015) 43 (5): 908–912.
Published: 09 October 2015
...Mark Shepherd The CydDC complex of Escherichia coli is a heterodimeric ATP-binding cassette (ABC) transporter that exports cysteine and glutathione to the periplasm. These reductants are thought to modulate periplasmic redox poise, impacting upon the disulfide folding of periplasmic and secreted...
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Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... of this subfamily may have the same function. Human ABCB6 can also partially complement a yeast atm1 mutant [ 5 ] but differences in the intracellular localization of ABCB6 and Atm1 may point to distinct physiological roles. ATP-binding cassette (ABC) transporter glutathione haem iron mitochondria...
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Biochem Soc Trans (2015) 43 (4): 632–638.
Published: 03 August 2015
...Edward E. Schmidt NADPH transfers reducing power from bioenergetic pathways to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR) to support essential reductive systems. Surprisingly, it was recently shown that mouse livers lacking both TrxR1 and GR (‘TR/GR-null’) can sustain redox...
Articles
Biochem Soc Trans (2014) 42 (5): 1286–1290.
Published: 18 September 2014
.... Canevari L. Duchen M.R. Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity J. Neurosci. 2003 23 5088 5095 12832532 8 Arispe N. Pollard H.B. Rojas E. Giant multilevel cation channels formed by Alzheimer disease...
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Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... to be elevated for several days, which has usually been interpreted to reflect increased ROS production. Levels of the antioxidant molecule GSH (reduced glutathione) are depleted for 1 month or longer following ultra-endurance exercise, suggesting an impaired capacity to cope with ROS. The present paper...
Articles
Biochem Soc Trans (2014) 42 (4): 905–908.
Published: 11 August 2014
.... Bulleid N.J. The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress EMBO Rep. 2006 7 271 275 10.1038/sj.embor.7400645 16607396 5 Jessop C.E. Chakravarthi S. Garbi N. Hammerling G.J. Lovell S. Bulleid N.J. ERp57...
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Biochem Soc Trans (2014) 42 (4): 979–984.
Published: 11 August 2014
...Bruce Morgan Glutathione is the most abundant small molecule thiol in nearly all eukaryotes. Whole-cell levels of oxidized (GSSG) and reduced (GSH) glutathione are variable and responsive to genetic and chemical manipulations, which has led to their relative levels being widely used as a marker...
Articles
Biochem Soc Trans (2014) 42 (2): 491–494.
Published: 20 March 2014
...Makoto Arai; Naomi Nihonmatsu-Kikuchi; Masanari Itokawa; Naila Rabbani; Paul J. Thornalley Glyoxalase I catalyses the isomerization of the hemithioacetal formed non-enzymatically from methylglyoxal and glutathione to S - D -lactoylglutathione. The activity of glyoxalase I is conventionally measured...
Articles
Biochem Soc Trans (2014) 42 (2): 413–418.
Published: 20 March 2014
...) discovered that glutathione (GSH) was a specific and essential cofactor for methylglyoxal metabolism by the glyoxalase system [ 9 ]. Maurice Jowett and Juda Quastel presented evidence that GSH and methylglyoxal combined reversibly to form a hemithioacetal substrate of the glyoxalase system [ 10 ]. Samuro...
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Biochem Soc Trans (2011) 39 (5): 1268–1272.
Published: 21 September 2011
...Lucia Coppo; Pietro Ghezzi Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug...
Articles
Biochem Soc Trans (2011) 39 (5): 1273–1278.
Published: 21 September 2011
... ). 2 Present address: Birmingham Dental School, St Chad's Queensway, Birmingham B4 6NN, U.K. 3 Present address: Abbott Laboratories, Abbott Park, IL 60064, U.S.A. 18 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ageing glutathione...
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Biochem Soc Trans (2005) 33 (6): 1397–1398.
Published: 26 October 2005
... expression patterns during lactation and after weaning and the possible functions of GSH in the modulation of these events. 1 To whom correspondence should be addressed (email Juan.R.Vina@uv.es ). 30 6 2005 © 2005 The Biochemical Society 2005 glutathione lactation mammary gland...
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Biochem Soc Trans (2005) 33 (6): 1390–1393.
Published: 26 October 2005
... of protein thiols with the endogenous glutathione pool. Protein glutathionylation and disulphide formation are of significance both for defence against oxidative damage and in redox signalling. As mitochondria are central to both oxidative damage and redox signalling within the cell, these modifications...
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Biochem Soc Trans (2005) 33 (6): 1378–1381.
Published: 26 October 2005
... The Biochemical Society 2005 antioxidant disulphide glutathione glutathionylation redox regulation thiol Aerobic organisms reduce molecular oxygen (O 2 ) to water during respiration. However, the interaction with biological systems also generates intermediate steps in the reduction of O 2...
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Biochem Soc Trans (2004) 32 (5): 655–658.
Published: 26 October 2004
... in vitro but also the requirement of these proteins to catalyse this reaction in vivo . 1 To whom correspondence should be addressed (email neil.bulleid@man.ac.uk ). 27 5 2004 © 2004 The Biochemical Society 2004 disulphide bond endoplasmic reticulum folding glutathione...
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Biochem Soc Trans (2004) 32 (6): 990–993.
Published: 26 October 2004
... discovered a common polymorphism in a part of the glutathione peroxidase 4 gene which corresponds to the 3′-UTR, and our recent results suggest that this single-nucleotide polymorphism has functional and physiological effects, as well as altered frequency in disease. 1 email j.e.hesketh@ncl.ac.uk...
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Biochem Soc Trans (2004) 32 (1): 151–155.
Published: 01 February 2004
... of the intracellular antioxidant glutathione. At high concentrations apoptosis occurs through mechanisms that have yet to be defined in detail. Recent studies have revealed a mechanism through which electrophilic lipids, formed as the reaction products of oxidation, orchestrate these adaptive responses...
Articles
Biochem Soc Trans (2003) 31 (6): 1406–1408.
Published: 01 December 2003
... of exposure to MG is best understood in the Gram-negative bacteria. The major mechanism of protection is the spontaneous reaction of MG with GSH to form hemithiolacetal, followed by detoxification by the glyoxalase system leading to the production of d-lactate. The KefB and KefC glutathione-gated K + efflux...
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Biochem Soc Trans (2003) 31 (6): 1343–1348.
Published: 01 December 2003
... reactions mediated by methylglyoxal, glyoxal and other α-oxoaldehydes in vivo . glutathione glycation glyoxalase methylglyoxal oxidative stress Abbreviations used: AGE, advanced glycation end-product; CDNB, 1-chloro-2,4-dinitrobenzene; SpBrBzGSH, S - p -bromobenzylglutathione; SpBrBzGSHCp...
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Biochem Soc Trans (2003) 31 (6): 1308–1311.
Published: 01 December 2003
... be addressed (e-mail hans.nohl@vu-wien.ac.at ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 ATPase activity bc 1 complex glutathione hydrogen peroxide mitochondria superoxide...
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Biochem Soc Trans (2002) 30 (4): 755–758.
Published: 01 August 2002
... of the antioxidant glutathione, indicating the role of oxidative stress in their toxicity. K562 cells loaded with eicosapentaenoic acid, a fatty acid particularly susceptible to oxidation, were also more sensitive to the toxic effects of the Fe complexes, and toxicity was proportional to lipid peroxidation. Thus...
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Biochem Soc Trans (2001) 29 (6): 717–722.
Published: 01 November 2001
...G. J. McBean; J. Flynn The transport of l -cystine into cells of the mammalian brain is an essential step in the supply of cysteine for synthesis of the antioxidant glutathione. Uptake of l cystine in rat brain synaptosomes occurs by three mechanisms that are distinguishable on the basis...
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Biochem Soc Trans (2000) 28 (2): 56–61.
Published: 01 February 2000
... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...
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Biochem Soc Trans (1982) 10 (2): 82–84.
Published: 01 April 1982
...BRIAN KETTERER; DENNIS BEALE; DAVID MEYER © 1982 Biochemical Society 1982 GSH glutathione 82 BIOCHEMICAL SOCIETY TRANSACTIONS glutathione S-transferases where the conjugates may be biologically important molecules. The slow-reacting substance of anaphylaxis was originally described...