... simulate effects of drug-induced inhibition of reaction steps on the whole-body physiology. We illustrate the approach for glucose metabolism in malaria patients, by merging two detailed kinetic models for glucose metabolism in the parasite Plasmodium falciparum and the human red blood cell with a coarse...

...Claire Bonal; Isabelle Avril; Pedro L. Herrera The control of glucose metabolism by pancreatic endocrine cells throughout life relies on a tight regulation of the mass of insulin-producing β-cells. How this homoeostasis is achieved is not well understood. Over the last few years, experimental...

... are impaired. 1 To whom correspondence should be addressed (email frances.ashcroft@physiol.ox.ac.uk ). 24 7 2006 © 2006 The Biochemical Society 2006 β-cell glucose metabolism nicotinamide nucleotide transhydrogenase (Nnt) oxidative stress reactive oxygen species Type 2 diabetes...

... that recently emerged as having a major impact on lipid and possibly glucose metabolism are the ANGPTLs (angiopoietin-like proteins). This includes ANGPTL3, ANGPTL4/FIAF (fasting-induced adipose factor), and ANGPTL6/AGF (angiopoietin-related growth factor). Although the receptors for these proteins have yet...

... transcription, glucose metabolism, lipid metabolism, nuclear receptor. Abbreviations used: ABCA1, ATP binding cassette A1; BARE, bile acid-responsive element; CYP7A1, cholesterol 7 -hydroxylase; FTF, -fetoprotein transcription factor; FXR/BAR, farnesoid X receptor; HNF-4, hepatocyte nuclear factor-4; LDL, low...

... Protein Kinase, a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002 10 September 2002 Copyright 2003 Biochemical Society 2003 glucose metabolism insulin resistance Abbreviations used: AMPK, AMP-activated protein kinase; ACC...