.... In addition, we discuss interactions between these nutrient/metabolite-responsive NRs and NRs that are central to the action of metabolically important hormones, including (i) the glucocorticoid receptor, critical for maintaining glucose homoeostasis in stress, inflammation and during fasting, and (ii...

... of transcription. A receptor of glucocorticoid, a potent anti-inflammatory agent, is also a target of acetylation. The glucocorticoid receptor is highly acetylated after ligand binding but its deacetylation is necessary for gene repression through binding to NF-κB. As well as acetylation, other PTMs...

...S.L. Lightman Hormones are characteristically secreted in distinct pulses. Corticosterone (in rodents) and cortisol (in human) show profound circadian and ultradian rhythmicity which results in rapid changes in ligand concentration in the circulating blood. The pattern of ultradian glucocorticoid...

.... Not all regulatory interactions are shown. ANP, atrial natriuretic peptide; CTB, cholera toxin B subunit; GC, glucocorticoid. The immunosuppressive cytokine TGF-β (transforming growth factor β) can also induce DUSP1 expression [ 34 , 34a ]. In the murine macrophage cell line RAW264.7, TGF-β co...

...F. Lang; V. Vallon; F. Grahammer; M. Palmada; C. Böhmer The serum- and glucocorticoid-inducible kinase SGK1 is an ubiquitously expressed kinase with the ability to regulate a variety of transport systems. Recent observations point to a role of SGK1 in the regulation of diverse physiological...

... factor; DR1, direct repeat 1; G3P, glycerol 3-phosphate; FA, fatty acid; PEPCK-C, cytosolic phosphoenolpyruvate carboxykinase (GTP); PPAR, peroxisome proliferator-activated receptor; TZD, thiazolidinedione; WAT, white adipose tissue. © 2003 Biochemical Society 2003 glucocorticoid peroxisome...

... glucocorticoid liver transdifferentiation Metabolite Channelling and Metabolic Complexity Graham, L. D. and Pertlam, R. N. ( I 990) FEBS Lett. 262, 20 24 1-244 Wallis, N. G., Allen, M. D., Broadhurst, R. W., Lessard, 21 I . A. D. and Perham, R. N. ( I 996) J. Mol. Biol. 263, 436474 22 kvarsson, A., Seger, K...