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Biochem Soc Trans (2021) 49 (6): 2561–2572.
Published: 02 December 2021
... in these genes in cancer were long thought to lead to a ‘loss of function’, combined genomic and metabolomic studies led to the discovery that a common IDH 1 mutation, present in low-grade glioma and acute myeloid leukaemia (AML), yields a variant (R132H) with a striking change of function leading...
Biochem Soc Trans (2021) 49 (1): 519–529.
Published: 05 February 2021
.... The abnormal regulation of RING E3s has been reported to disrupt normal biological processes and induce the occurrence of many human malignancies. Glioma is the most common type of malignant primary brain tumor. In the last few decades, patient prognosis has improved as novel targeted therapeutic agents have...
Biochem Soc Trans (2019) 47 (5): 1471–1479.
Published: 24 September 2019
...Jong Fu Wong; Elizabeth J. Brown; Eleanor Williams; Alex N. Bullock Brain tumours have become the leading cause of child mortality from cancer. Indeed, aggressive brainstem tumours, such as diffuse intrinsic pontine glioma (DIPG), are nearly uniformly fatal. These tumours display a unique set...
Biochem Soc Trans (2016) 44 (6): 1683–1693.
Published: 02 December 2016
... by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss...
Karolina Janczar, Zhangjie Su, Isabella Raccagni, Andrea Anfosso, Charlotte Kelly, Pascal F. Durrenberger, Alexander Gerhard, Federico Roncaroli
Biochem Soc Trans (2015) 43 (4): 579–585.
Published: 03 August 2015
...Karolina Janczar; Zhangjie Su; Isabella Raccagni; Andrea Anfosso; Charlotte Kelly; Pascal F. Durrenberger; Alexander Gerhard; Federico Roncaroli The 18-kDa mitochondrial translocator protein (TSPO) is known to be highly expressed in several types of cancer, including gliomas, whereas expression...
Davide Danovi, Anna Falk, Peter Humphreys, Richard Vickers, Jon Tinsley, Austin G. Smith, Steven M. Pollard
Biochem Soc Trans (2010) 38 (4): 1067–1071.
Published: 26 July 2010
... adherent culture conditions that enable expansion of human radial glia-like fetal NS (neural stem) cells as stable cell lines. Similar protocols proved effective in the establishment of tumour-initiating stem cell lines from the human brain tumour glioblastoma multiforme, which we termed GNS (glioma NS...