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Keywords: genome-wide association studies
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Biochem Soc Trans (2019) 47 (2): 651–661.
Published: 05 March 2019
... penetrance and genome-wide association studies have found variants of the gene that are risk factors for sporadic PD. Functional studies have suggested that the common mechanism that links all disease-associated variants is that they increase LRRK2 kinase activity, albeit in different ways. Here, we...