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Keywords: genome stability
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Articles
Biochem Soc Trans (2014) 42 (4): 717–725.
Published: 11 August 2014
..., cellular and developmental studies of this enzyme. These investigations have culminated in establishing this enzyme as a key genome-surveillance enzyme required for mammalian genome stability. Aicardi–Goutières syndrome autoinflammation genome stability ribonuclease H2 ribonucleotide incorporation...
Articles
Biochem Soc Trans (2011) 39 (1): 58–63.
Published: 19 January 2011
... topology genome stability topoisomerase Maintaining the appropriate sign and density of DNA supercoiling is vital for any cell. DNA supercoiling plays a major role in many cellular functions, including DNA packaging, gene regulation and recombination. Conversely, most DNA activities, as well...
Articles
Biochem Soc Trans (2009) 37 (4): 926–930.
Published: 22 July 2009
... to biomedical researchers, and detailed knowledge of these mechanisms may lead to the identification of novel molecular targets for drug therapies in cancer and other diseases. Cdc45 cell cycle checkpoint DNA damage DNA replication genome stability 1 To whom correspondence should...
Articles
Biochem Soc Trans (2009) 37 (4): 910–913.
Published: 22 July 2009
... is dependent on the extent of aneuploidy induced. The mitotic checkpoint plays a pivotal role in the maintenance of genome stability and has been the focus of work investigating the distinct outcomes of aneuploidy. In the present article, we review the molecular mechanisms involved and discuss the potential...
Articles
Biochem Soc Trans (2009) 37 (1): 69–73.
Published: 20 January 2009
..., and degradation of other proteins in response to DNA damage has not been shown to date. Whereas the reported evidence supports the hypothesis that reverse gyrase is involved in maintenance of genome stability, its exact role in physiological growth and in the cell response to DNA damage is not understood...
Articles
Biochem Soc Trans (2007) 35 (6): 1379–1384.
Published: 23 November 2007
... conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe , Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report...
Articles
Biochem Soc Trans (2007) 35 (6): 1385–1388.
Published: 23 November 2007
... The Authors Journal compilation © 2007 Biochemical Society 2007 genome stability DNA replication proliferating-cell nuclear antigen (PCNA) small ubiquitin-related modifier (SUMO) Srs2 yeast E1 ubiquitin- or SUMO-activating enzyme E2 ubiquitin- or SUMO-conjugating enzyme E3...
Articles
Biochem Soc Trans (2007) 35 (5): 1334–1337.
Published: 25 October 2007
... the common principles that emerge from the genetic and biochemical studies of damage tolerance in a range of experimental systems. 1 email helle.ulrich@cancer.org.uk 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 DNA replication genome stability...