..., cellular and developmental studies of this enzyme. These investigations have culminated in establishing this enzyme as a key genome-surveillance enzyme required for mammalian genome stability. In contrast with eukaryotes, type 2 RNase H enzymes are monomeric in prokaryotes. The eukaryotic homologue...

... (email m.ciaramella@ibp.cnr.it ). 8 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 architectural protein chromosome structure DNA topology genome stability topoisomerase Maintaining the appropriate sign and density of DNA supercoiling is vital...

... is dependent on the extent of aneuploidy induced. The mitotic checkpoint plays a pivotal role in the maintenance of genome stability and has been the focus of work investigating the distinct outcomes of aneuploidy. In the present article, we review the molecular mechanisms involved and discuss the potential...

... 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Cdc45 cell cycle checkpoint DNA damage DNA replication genome stability In all organisms, including humans, accurate chromosomal DNA replication is essential to maintain stability of the genome...

... at high temperature, thus confirming a specific role of the enzyme in thermoadaptation [ 11 ]. archaeon DNA topology genome stability helicase hyperthermophile topoisomerase DNA topoisomerases are essential enzymes that regulate the topological state of DNA in all cells throughout...

... conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe , Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report...

...-like proteins, common to all eukaryotes. Modification by SUMO has been implicated in the control of numerous biological processes, ranging from nucleocytoplasmic transport to the regulation of transcription, chromosome segregation and genome stability. These functions have been discussed in several...

... ], it appears to be partially required for damage-induced mutagenesis in yeast [ 45 ]. 1 email helle.ulrich@cancer.org.uk 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 DNA replication genome stability mutagenesis translesion synthesis ubiquitin...