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Keywords: genome editing
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Biochem Soc Trans (2020) 48 (1): 15–23.
Published: 10 January 2020
.... The compact class 2 systems, that hinge on a single Cas effector nuclease have been harnessed for genome editing, transcriptional regulation, detection, imaging and other applications, in different research areas. However, most of the CRISPR-Cas systems belong to class 1, and the molecular machinery...
Biochem Soc Trans (2020) 48 (1): 207–219.
Published: 24 December 2019
...Thomas Swartjes; Raymond H.J. Staals; John van der Oost Discovered as an adaptive immune system of prokaryotes, CRISPR–Cas provides many promising applications. DNA-cleaving Cas enzymes like Cas9 and Cas12a, are of great interest for genome editing. The specificity of these DNA nucleases...
Biochem Soc Trans (2019) 47 (5): 1499–1510.
Published: 11 October 2019
... repurposed as a genetic tool for programmable genome editing and transcriptional control in both prokaryotic and eukaryotic cells. In addition, its trans -cleavage activity has been applied for high-sensitivity nucleic acid detection. Despite the demonstrated value of Cas12a for these applications, the exact...