... variety of neurological disorders; therefore, discovering molecular regulators of memory may reveal therapeutic targets for these disorders. C. elegans are an excellent model to uncover molecular and genetic regulators of memory. Indeed, the nematode's invariant neuronal lineage, fully mapped genome...

... homology, which is compounded by low genetic tractability compared with many model organisms. In recent years technical breakthroughs have made forward and reverse genome-scale screens in Plasmodium possible. Furthermore, the adaptation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR...

... by Portland Press Limited on behalf of the Biochemical Society 2021 cell homeostasis genetics innate immunity model organisms Figure 1. C. elegans is readily amenable to study at multiple scales. ( A ) Top panels: from the whole animal to the cellular scale; photomicrographs, merging...

... in DNA sequencing technology have allowed us to survey the complexities that constitute the cancer genome, while advances in genetic engineering are allowing us to functionally interrogate these alterations. These approaches are providing new insights into how mutations influence cancer biology...

...John Hardy For each of the neurodegenerative syndromes, we now know many pathogenic and/or causative genetic risk loci. Here, I suggest that this wealth of knowledge now allows us to start to understand what are the specific vulnerabilities of different neuronal types and to suggest that each...

...Donatella Peca; Renato Cutrera; Andrea Masotti; Renata Boldrini; Olivier Danhaive Genetic disorders of the surfactant system are rare diseases with a broad range of clinical manifestations, from fatal respiratory distress syndrome (RDS) in neonates to chronic interstitial lung disease (ILD...

... attention to TSPO genetics, cellular heterogeneity of TSPO in brain tissue and TSPO distribution in blood and plasma that need to be considered in the quantification of PET data to avoid spurious results as well as ineffective development and use of these radiotracers. 1 To whom correspondence should...

... both gene-driven (reverse genetics) and phenotype-driven (forward genetics) approaches. A high-efficiency ENU approach results in approx. 25 functional mutations per genome; most of these will result in hypomorphic alleles. Our group has recently begun using ENU mutagenesis as a tool for understanding...

...Michaela Wagner; Silvia Berkner; Malgorzata Ajon; Arnold J.M. Driessen; Georg Lipps; Sonja-Verena Albers Although Sulfolobus species are among the best studied archaeal micro-organisms, the development and availability of genetic tools has lagged behind. In the present paper, we discuss the latest...

...Anna L. Gloyn; Nicholas D. Tribble; Martijn van de Bunt; Amy Barrett; Paul R.V. Johnson There are well-documented examples in the literature of where determining the genetic aetiology of a disorder has provided insights into important regulatory pathways and protein interactions, and, more recently...

... surviving neurons. Although heritability studies have shown evidence of familial aggregation, twin studies have provided limited support for a genetic aetiology. Nevertheless, classical linkage methods have nominated 11 regions of the genome and pathogenic mutations have been identified in several genes...

... and molecular genetic characteristics that are ideal for its glucose sensor function and allow it to control glycolytic flux of the β-cells as indicated by control-, elasticity- and response-coefficients close to or larger than 1.0. GK operates in tandem with the K + and Ca 2+ channels of the β-cell membrane...

... to aging. 1 To whom correspondence should be addressed (e-mail bz@soton.ac.uu ). 678th Meeting of the Biochemical Society, held at Imperial College, London, 16–18 December 2002 11 November 2002 Copyright 2003 Biochemical Society 2003 aging association study genetics...

... pathology indicates that absent or shallow invasion of foetal trophoblasts into maternal arteries is a feature of true PE. The objective of this study was to determine the genetic factors influencing PE. A large number of mother-father-baby trios were collected in which the first pregnancy was complicated...