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Keywords: genetically engineered mouse model
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Biochem Soc Trans (2007) 35 (5): 1329–1333.
Published: 25 October 2007
..., indicating that BRAF and MEK are attractive therapeutic targets in cancer samples with BRAF mutations. In order to fully understand the role of oncogenic BRAF in cancer development in vivo as well as to test the in vivo efficacy of anti-BRAF or anti-MEK therapies, GEMMs (genetically engineered mouse models...