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Keywords: gene therapy
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Articles
Biochem Soc Trans (2021) 49 (6): 2539–2548.
Published: 09 December 2021
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . alpha cell diabetes gene therapy Type 1 diabetes is a chronic disease characterized by autoimmune-mediated destruction of the insulin-producing β cells in the pancreas [ 1 ]. Destruction of β...
Includes: Supplementary data
Articles
Biochem Soc Trans (2021) 49 (5): 2443–2454.
Published: 28 October 2021
...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with EBSCO. gene therapy HOIL-1L HOIP LUBAC M1 ubiquitination ubiquitin ligases A subset of patients suffer immunodeficiency, systemic inflammation of multiple organs...
Articles
Biochem Soc Trans (2018) 46 (5): 1247–1261.
Published: 09 October 2018
... The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bypass therapy gene therapy mitochondrial biogenesis mitochondrial dysfunction rapamycin...
Articles
Biochem Soc Trans (2018) 46 (1): 11–21.
Published: 01 December 2017
... on behalf of the Biochemical Society 2018 cardiovascular disease gene therapy high-throughput screening microRNA The foundation of molecular biology states that DNA is copied to RNA by the process of transcription. The transcribed RNA then translates the information to produce proteins...
Articles
Biochem Soc Trans (2016) 44 (5): 1355–1365.
Published: 19 October 2016
... and adverse effects. Therefore, more durable therapeutic strategies should be considered, such as a stable gene therapy to protect the target T cells against HIV-1 infection. The development of potent therapeutic regimens based on the RNA interference (RNAi) and clustered regularly interspaced short...
Articles
Biochem Soc Trans (2016) 44 (5): 1483–1490.
Published: 19 October 2016
... reviewed. © 2016 The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models...
Articles
Biochem Soc Trans (2011) 39 (2): 584–588.
Published: 22 March 2011
..., College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K. 2 9 2010 Pairs of ZFNs designed to act at two adjacent sequences have been widely advocated as potential tools for targeting individual genes and for gene therapy [ 43 – 45 ]. Nevertheless, while ZFNs constructed along...
Articles
Biochem Soc Trans (2010) 38 (6): 1484–1488.
Published: 24 November 2010
...-like growth factor) II receptor provides an avenue for endocytosis, trafficking and lysosomal processing of extracellularly delivered enzyme. The present review discusses therapeutic utilization of cross-correction by enzyme-replacement therapy, gene therapy and stem cell therapy for the NCLs, along...
Articles
Biochem Soc Trans (2010) 38 (6): 1489–1493.
Published: 24 November 2010
... ). 15 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene therapy in utero gene transfer lysosomal storage disorder mouse nervous system viral vector Early lethal genetic diseases of the nervous system are individually rare, yet collectively numerous...
Articles
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
... myocardium [ 18 ]. Gene therapy results from small animal models are easily overinterpreted regarding their applicability to the human clinical situation. It is obviously easier to transduce the entire muscle in the mouse than human muscle masses hundreds of times larger. Therefore further development...
Articles
Biochem Soc Trans (2003) 31 (2): 397–406.
Published: 01 April 2003
... molecular probes as tools to throw light on the problematic steps in non-viral gene delivery which still impede efficient gene therapy. Thus, the current aims of our research are to understand, design and prepare small-molecule lipopolyamines for non-viral gene therapy (NVGT). The rational design...