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Keywords: gene expression
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Articles
Biochem Soc Trans (2022) 50 (1): 187–198.
Published: 23 December 2021
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . challenges gene expression multifunctionality SR proteins Serine/arginine-rich splicing factors (SRSFs, SR proteins) are a phylogenetically conserved family of RNA-binding proteins (RBPs) present in all metazoans...
Articles
Biochem Soc Trans (2018) 46 (1): 111–118.
Published: 12 January 2018
.... Correspondence: Francis Stephens ( f.b.stephens@exeter.ac.uk ) * These authors contributed equally to this work. 4 9 2017 23 11 2017 24 11 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 exercise gene expression...
Articles
Biochem Soc Trans (2017) 45 (4): 987–997.
Published: 14 July 2017
...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...
Articles
Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
... : rheumatoid arthritis; PACER : several cancers including osteosarcoma. biomarkers disease gene expression inflammation lncRNA transcriptional regulation The ‘noncoding revolution’ [ 1 ] has reformed our understanding of how the eukaryotic genomic code is arranged, regulated...
Articles
Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell free gene expression modelling prototyping synthetic biology Cell-free systems represent a historically important component of the founding of the field of biochemistry. Ever since the pioneering efforts...
Articles
Biochem Soc Trans (2016) 44 (4): 1051–1057.
Published: 15 August 2016
... monophosphates, the poly(A) tail, by poly(A) polymerase. This schematic is highly simplified, and does not depict the interactions between the cleavage factors, nor the full range of proteins that may contribute to cleavage and polyadenylation. cancer cell proliferation gene expression mRNA biogenesis...
Articles
Biochem Soc Trans (2016) 44 (1): 279–285.
Published: 09 February 2016
... in inositide metabolism, nuclear signalling and transcriptional regulation. 30 11 2015 © 2016 Authors; published by Portland Press Limited 2016 IPMK ipk2 ArgR inositide multikinase transcription gene expression Inositides represent a large family of secondary messengers...
Articles
Biochem Soc Trans (2014) 42 (6): 1647–1652.
Published: 17 November 2014
... of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment. 1 email anna.dimberg@igp.uu.se 13 10 2014 © The Authors Journal compilation ©...
Articles
Biochem Soc Trans (2014) 42 (5): 1409–1413.
Published: 18 September 2014
... Biochemical Society 2014 gene expression histone variant lipid metabolism nucleosome steatosis Canonical histones (H2A, H2B, H3 and H4) are assembled into nucleosomes during DNA replication to package it into chromatin. In contrast, histone variants are deposited independently of replication...
Articles
Biochem Soc Trans (2014) 42 (4): 1190–1195.
Published: 11 August 2014
... accepted status as a major player in the regulation of eukaryotic gene expression. Although ~70% of human genes have been shown to contain multiple cleavage and polyadenylation sites, the extent of the consequences of APA and its role in regulating physiological processes are still largely unknown...
Articles
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Cassette exons are the most frequent form of alternative splicing in human and mouse cells. A key feature of several Tra2 protein-regulated exons are multiple individual Tra2-binding sites within the target RNA...
Articles
Biochem Soc Trans (2014) 42 (2): 495–499.
Published: 20 March 2014
... I) and Glo2 (glyoxalase II) may be induced or suppressed, and rates of proteolysis of Glo1 and Glo2 proteins may change in health and disease. Quantitative assessment of glyoxalase gene expression at the mRNA and protein levels has become a key part of glyoxalase system characterization. For mRNA...
Articles
Biochem Soc Trans (2014) 42 (2): 500–503.
Published: 20 March 2014
... 2014 Biochemical Society 2014 anxiety copy number variation gene expression glyoxalase methylglyoxal tumour The glyoxalase system consists of two enzymes: Glo1 (glyoxalase I) and Glo2 (glyoxalase II) and a catalytic amount of reduced glutathione (GSH). The major function...
Articles
Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
...Emma J. Mead; Rosalyn J. Masterton; Tobias von der Haar; Mick F. Tuite; C. Mark Smales Translational control is central to the gene expression pathway and was the focus of the 2013 annual Translation UK meeting held at the University of Kent. The meeting brought together scientists at all career...
Articles
Biochem Soc Trans (2014) 42 (1): 184–187.
Published: 23 January 2014
... of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2–Pan3 deadenylation complex. 1...
Articles
Biochem Soc Trans (2014) 42 (1): 155–159.
Published: 23 January 2014
... to many other biological/medical questions/fields. 1 email tamirtul@post.tau.ac.il 12 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biological model codon bias gene expression gene translation systems biology Codon bias is defined...
Articles
Biochem Soc Trans (2013) 41 (3): 741–749.
Published: 23 May 2013
... dimethyl-H3K4 (a signal which potentiates gene expression) which, in combination with deacetylation of H3, synergize to repress active transcription. The canonical Sin3A complex alone appears to contain only deacetylase activity [ 19 , 25 ]. How are HDAC1/2 recruited to such diverse complexes? Both MTA...
Articles
Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle...
Articles
Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... Journal compilation © 2012 Biochemical Society 2012 development gene expression high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) RNA-binding proteins RNA splicing Tra2β transcriptome Alternative splicing introduces new coding information...
Articles
Biochem Soc Trans (2011) 39 (6): 1735–1741.
Published: 21 November 2011
... membrane are involved in tethering chromatin to the nuclear envelope and affect gene expression. They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, BAF (barrier to autointegration factor). Interestingly, this domain...
Articles
Biochem Soc Trans (2010) 38 (6): 1598–1601.
Published: 24 November 2010
..., the inhibitory by-product of methylation reactions. 1 email v.h.cowling@dundee.ac.uk 31 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell proliferation gene expression 7-methylguanosine cap mRNA translation c-Myc transcription The Myc...
Articles
Biochem Soc Trans (2010) 38 (6): 1500–1505.
Published: 24 November 2010
... ). 7 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression nonsense-mediated mRNA decay (NMD) premature termination codon (PTC) RNA decay RNA processing RNA quality control Severo Ochoa won the 1959 Nobel Prize in Medicine after he...
Articles
Biochem Soc Trans (2010) 38 (6): 1531–1536.
Published: 24 November 2010
...Katrin Wiederhold; Lori A. Passmore The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly...
Articles
Biochem Soc Trans (2010) 38 (6): 1495–1499.
Published: 24 November 2010
... rapidly, as regulation of these multiple steps in gene expression is implicated in diverse aspects of biology such as metabolism, neurology, reproduction and viral lifecycle regulation. Researchers who utilize various combinations of human studies, animal models, cellular, genetic, biochemical...
Articles
Biochem Soc Trans (2010) 38 (4): 1125–1130.
Published: 26 July 2010
... ancestor with a diverse set of spliced leader RNA genes. 1 To whom correspondence should be addressed (email b.mueller@abdn.ac.uk ). 26 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 eukaryote gene expression metazoan RNA processing RNA splicing...
Articles
Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
...Ian C. Wood; Nicola K. Gray; Lesley Jones The brain is the most complex organ of the body and it contains the greatest diversity of cell types. Collectively, the cells within the brain express the greatest number of genes encoded within our genome. Inappropriate gene expression within these cells...
Articles
Biochem Soc Trans (2009) 37 (6): 1276–1277.
Published: 19 November 2009
...John Hardy; Danyah Trabzuni; Mina Ryten Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases...
Articles
Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
Articles
Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
...Ian G. Cannell; Yi Wen Kong; Martin Bushell miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational...
Articles
Biochem Soc Trans (2008) 36 (4): 708–711.
Published: 22 July 2008
...Laura Smith Post-transcriptional regulation, via 5′-UTRs (5′-untranslated regions), plays an important role in the control of eukaryotic gene expression. Recent analyses of the mammalian transcriptome suggest that most of the genes express multiple alternative 5′-UTRs and inappropriate expression...
Articles
Biochem Soc Trans (2008) 36 (3): 534–536.
Published: 21 May 2008
... adenosine deaminase that acts on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation The role of dsRNA (double-stranded RNA) in cells has been the subject of much recent research following the finding that it is an essential component of the RNAi (RNA...
Articles
Biochem Soc Trans (2008) 36 (3): 540–542.
Published: 21 May 2008
.... Synthetic activities during spermatogenesis in the mouse Exp. Cell Res. 1965 39 197 224 5 Schultz N. Hamra F. Garbers D. A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets Proc. Natl. Acad. Sci. U.S.A...
Articles
Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
...Oliver Mühlemann Among the different cellular surveillance mechanisms that ensure accurate gene expression, nonsense-mediated mRNA decay rapidly degrades mRNAs harbouring PTCs (premature translation-termination codons) and thereby prevents the accumulation of potentially deleterious proteins with C...
Articles
Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... chronic exposure, specific amino acids may influence gene expression in the β-cell, which have an impact on insulin secretion and cellular integrity. Therefore amino acids may play a direct or indirect (via generation of putative messengers of mitochondrial origin) role in insulin secretion. 1...
Articles
Biochem Soc Trans (2006) 34 (6): 1138–1140.
Published: 25 October 2006
... hypertrophy can result in heart failure. One characteristic of hypertrophy is the re-expression of genes that are normally only expressed during foetal heart development. Although the involvement of these changes in gene expression in hypertrophy has been known for some years, the mechanisms involved...
Articles
Biochem Soc Trans (2006) 34 (6): 1141–1144.
Published: 25 October 2006
... cholesterol homoeostasis gene expression lipoprotein lipase (LPL) transforming growth factor-β (TGF-β) The TGF-β superfamily comprises over 30 members that include TGF-β and a number of related factors (e.g. activins, nodals, bone morphogenetic proteins/growth and differentiation factors) [ 1...
Articles
Biochem Soc Trans (2006) 34 (5): 705–710.
Published: 25 October 2006
...-associated herpesvirus). All herpesviruses are nuclear replicating viruses that subvert cellular processes such as nucleocytoplasmic transport for their advantage. For virus replication to take over the cell and produce lytic infection requires that virus gene expression outpace that of the host cell. KSHV...
Articles
Biochem Soc Trans (2006) 34 (1): 30–34.
Published: 20 January 2006
...S.F. Newbury mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes...
Articles
Biochem Soc Trans (2005) 33 (5): 943–944.
Published: 26 October 2005
... genes are expressed rhythmically and have identified ‘clusters’ of metabolically related genes that are expressed at particular times of the day [ 2 ]. For example, several genes expressed in late subjective afternoon encode proteins that function in the storage, transport or utilization of sugars...
Articles
Biochem Soc Trans (2005) 33 (4): 665–666.
Published: 01 August 2005
... 1 email clarkear@cf.ac.uk 30 3 2005 © 2005 The Biochemical Society 2005 adenomatous polyposis coli (APC) β-catenin colorectal cancer gene expression The APC (adenomatous polyposis coli) gene encodes the APC tumour suppressor protein, germline mutation of which...
Articles
Biochem Soc Trans (2005) 33 (4): 730–732.
Published: 01 August 2005
... (deleted in malignant brain tumour-1) gene expression tumour suppressor Changes in the glycosylation of a variety of glycoproteins, including mucins and tumour-suppressor-gene products, feature among the many studies designed to investigate the mechanisms of malignant transformation in CRC...
Articles
Biochem Soc Trans (2005) 33 (4): 733–735.
Published: 01 August 2005
... that a reduction in MCT1 expression, and hence butyrate transport, can lead to a reduction in the intracellular butyrate levels required to regulate gene expression. Collectively, our results highlight the important contribution of butyrate transport to the maintenance of tissue homoeostasis and disease prevention...
Articles
Biochem Soc Trans (2005) 33 (3): 499–501.
Published: 01 June 2005
...R.W.P. Smith; P. Malik; J.B. Clements The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post...
Articles
Biochem Soc Trans (2004) 32 (6): 1100–1102.
Published: 26 October 2004
... important to the processes maintaining colonic tissue homoeostasis. 1 To whom correspondence should be addressed (email spsb@liv.ac.uk ). 13 7 2004 © 2004 The Biochemical Society 2004 dietary fibre gene expression intestine monocarboxylate nutrient transport Adaptation...
Articles
Biochem Soc Trans (2004) 32 (6): 999–1002.
Published: 26 October 2004
... interventions. 1 email hmroche@tcd.ie 25 8 2004 © 2004 The Biochemical Society 2004 fatty acid gene expression insulin resistance metabolic syndrome nutrigenomics sterol-regulatory-element-binding protein 1c (SREPB-1c) tumour necrosis factor-α (TNF-α) Nutritional genomics...
Articles
Biochem Soc Trans (2004) 32 (6): 1090–1092.
Published: 26 October 2004
... To whom correspondence should be addressed (email mwhite@liv.ac.uk ). 2 7 2004 © 2004 The Biochemical Society 2004 gene expression NF-κB oscillations transcription Oscillators, such as the circadian clock, segmentation clock or the cell cycle, are now well-characterized...
Articles
Biochem Soc Trans (2004) 32 (4): 565–566.
Published: 01 August 2004
... alternative polyadenylation floral transition gene expression The floral transition is complex, involving the integration of responses to environmental cues with an endogenous programme of development. These responses are mediated by genetically separable pathways, which ensure that flowering occurs...
Articles
Biochem Soc Trans (2004) 32 (1): 103–106.
Published: 01 February 2004
... Society 2004 cholesterol traffic fat cell gene expression lipid droplet sterol-response-element-binding protein (SREBP) triacylglycerol Abbreviations used: LDL, low-density lipoprotein; SREBP, sterol-response-element-binding protein; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA...
Articles
Biochem Soc Trans (2003) 31 (6): 1130–1132.
Published: 01 December 2003
... leads to reduction of adipocyte size and body fat mass. These data strongly suggest that PPAR δ controls fatty acid catabolism in muscle and that its activation by synthetic agonists could prevent or correct obesity and type 2 diabetes. © 2003 Biochemical Society 2003 fatty acid gene expression...
Articles
Biochem Soc Trans (2003) 31 (4): 806–809.
Published: 01 August 2003
... Society 2003 bactericidal/permeability-increasing protein (BPI) gene expression gene structure host defence innate immunity lipopolysaccharide-binding protein (LBP) palate lung and nasal epithelium clone (PLUNC) Abbreviations used: BASE, breast cancer and salivary expressed; BPI...