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Articles

Myosin in chromosome organisation and gene expression

Isabel W. Shahid-Fuente, Christopher P. Toseland

Biochem Soc Trans (2023) BST20220939.

DOI: https://doi.org/10.1042/BST20220939

Published: 12 May 2023

... by the participation of University of Sheffield in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. gene expression myosin nuclear myosin transcription The functions of the B-WICH complex also involve...

View article titled, Myosin in chromosome organisation and gene expression

Articles

The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation

Shang Liang, Rajaei Almohammed, Victoria H. Cowling

Biochem Soc Trans (2023) BST20221154.

DOI: https://doi.org/10.1042/BST20221154

Published: 05 May 2023

... of Glasgow in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. CMTR1 differentiation embryonic stem cells gene expression RNA cap RNMT The histones are the predominant CMTR1 target gene transcript...

View article titled, The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation

Includes: Supplementary data

Articles

Exploring the multifunctionality of SR proteins

Irena Slišković, Hannah Eich, Michaela Müller-McNicoll

Biochem Soc Trans (2022) 50 (1): 187–198.

DOI: https://doi.org/10.1042/BST20210325

Published: 23 December 2021

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . challenges gene expression multifunctionality SR proteins Serine/arginine-rich splicing factors (SRSFs, SR proteins) are a phylogenetically conserved family of RNA-binding proteins (RBPs) present in all metazoans...

View article titled, Exploring the multifunctionality of SR proteins

Articles

Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans

Francis B. Stephens, Kostas Tsintzas

Biochem Soc Trans (2018) 46 (1): 111–118.

DOI: https://doi.org/10.1042/BST20170198

Published: 12 January 2018

.... Correspondence: Francis Stephens ( f.b.stephens@exeter.ac.uk ) * These authors contributed equally to this work. 4 9 2017 23 11 2017 24 11 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 exercise gene expression...

View article titled, Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans

Articles

RNA search engines empower the bacterial intranet

Tom Dendooven, Ben F. Luisi

Biochem Soc Trans (2017) 45 (4): 987–997.

DOI: https://doi.org/10.1042/BST20160373

Published: 14 July 2017

...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...

View article titled, RNA search engines empower the bacterial intranet

Articles

Lnc-ing inflammation to disease

Loretta Magagula, Maria Gagliardi, Jerolen Naidoo, Musa Mhlanga

Biochem Soc Trans (2017) 45 (4): 953–962.

DOI: https://doi.org/10.1042/BST20160377

Published: 07 July 2017

... of the Biochemical Society 2017 biomarkers disease gene expression inflammation lncRNA transcriptional regulation The ‘noncoding revolution’ [ 1 ] has reformed our understanding of how the eukaryotic genomic code is arranged, regulated and transcribed. Simply defined as the transcribed yet...

View article titled, Lnc-ing inflammation to disease

Articles

Cell-free synthetic biology for in vitro prototype engineering

Simon J. Moore, James T. MacDonald, Paul S. Freemont

Biochem Soc Trans (2017) 45 (3): 785–791.

DOI: https://doi.org/10.1042/BST20170011

Published: 15 June 2017

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell free gene expression modelling prototyping synthetic biology Cell-free systems represent a historically important component of the founding of the field of biochemistry. Ever since the pioneering efforts...

View article titled, Cell-free synthetic biology for in vitro prototype engineering

Articles

Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation

Jessica G. Hardy, Chris J. Norbury

Biochem Soc Trans (2016) 44 (4): 1051–1057.

DOI: https://doi.org/10.1042/BST20160078

Published: 15 August 2016

... The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cancer cell proliferation gene expression mRNA biogenesis polyadenylation post-transcriptional regulation of gene expression The closely coupled cleavage and polyadenylation reactions are key steps...

View article titled, Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation

Articles

Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism

M. Merced Malabanan, Raymond D. Blind

Biochem Soc Trans (2016) 44 (1): 279–285.

DOI: https://doi.org/10.1042/BST20150225

Published: 09 February 2016

... gene expression Inositides represent a large family of secondary messengers that are essential in the regulation of various cellular processes. This group of molecules may be classified either as water-soluble inositol polyphosphates (IPs) or inositol lipids [(phosphatidylinositols...

View article titled, Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism

Articles

The glioblastoma vasculature as a target for cancer therapy

Anna Dimberg

Biochem Soc Trans (2014) 42 (6): 1647–1652.

DOI: https://doi.org/10.1042/BST20140278

Published: 17 November 2014

... of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment. 1 email anna.dimberg@igp.uu.se 13 10 2014 © The Authors Journal compilation ©...

View article titled, The glioblastoma vasculature as a target for cancer therapy

Articles

Histone variants and lipid metabolism

Michela Borghesan, Gianluigi Mazzoccoli, Fareeba Sheedfar, Jude Oben, Valerio Pazienza, Manlio Vinciguerra

Biochem Soc Trans (2014) 42 (5): 1409–1413.

DOI: https://doi.org/10.1042/BST20140119

Published: 18 September 2014

... Biochemical Society 2014 gene expression histone variant lipid metabolism nucleosome steatosis Canonical histones (H2A, H2B, H3 and H4) are assembled into nucleosomes during DNA replication to package it into chromatin. In contrast, histone variants are deposited independently of replication...

View article titled, Histone variants and lipid metabolism

Articles

Alternative polyadenylation: less than meets the eye?

Jonathan Neve, André Furger

Biochem Soc Trans (2014) 42 (4): 1190–1195.

DOI: https://doi.org/10.1042/BST20140054

Published: 11 August 2014

... accepted status as a major player in the regulation of eukaryotic gene expression. Although ~70% of human genes have been shown to contain multiple cleavage and polyadenylation sites, the extent of the consequences of APA and its role in regulating physiological processes are still largely unknown...

View article titled, Alternative polyadenylation: less than meets the eye?

Articles

Tra2 protein biology and mechanisms of splicing control

Andrew Best, Caroline Dalgliesh, Mahsa Kheirollahi-Kouhestani, Marina Danilenko, Ingrid Ehrmann, Alison Tyson-Capper, David J. Elliott

Biochem Soc Trans (2014) 42 (4): 1152–1158.

DOI: https://doi.org/10.1042/BST20140075

Published: 11 August 2014

... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Tra2 proteins are nuclear RNA-binding proteins involved in splicing regulation ( Figure 1 A). Tra2 proteins are conserved across the animal kingdom. Invertebrates have a single Tra2 protein copy (of which...

View article titled, Tra2 protein biology and mechanisms of splicing control

Articles

Measurement of glyoxalase gene expression

Mingzhan Xue, Naila Rabbani, Paul J. Thornalley

Biochem Soc Trans (2014) 42 (2): 495–499.

DOI: https://doi.org/10.1042/BST20140026

Published: 20 March 2014

... I) and Glo2 (glyoxalase II) may be induced or suppressed, and rates of proteolysis of Glo1 and Glo2 proteins may change in health and disease. Quantitative assessment of glyoxalase gene expression at the mRNA and protein levels has become a key part of glyoxalase system characterization. For mRNA...

View article titled, Measurement of glyoxalase gene expression

Articles

Copy number variation of glyoxalase I

Alaa Shafie, Mingzhan Xue, Paul J. Thornalley, Naila Rabbani

Biochem Soc Trans (2014) 42 (2): 500–503.

DOI: https://doi.org/10.1042/BST20140011

Published: 20 March 2014

... of substantial diversity of gene expression and phenotype [ 3 , 4 ], including in human subjects and related primates [ 5 , 6 ]. Although there has been rapid expansion of both CNV detection techniques as well as their application across a wide range of biological samples and species, fundamental questions about...

View article titled, Copy number variation of glyoxalase I

Articles

Control and regulation of mRNA translation

Emma J. Mead, Rosalyn J. Masterton, Tobias von der Haar, Mick F. Tuite, C. Mark Smales

Biochem Soc Trans (2014) 42 (1): 151–154.

DOI: https://doi.org/10.1042/BST20130259

Published: 23 January 2014

...Emma J. Mead; Rosalyn J. Masterton; Tobias von der Haar; Mick F. Tuite; C. Mark Smales Translational control is central to the gene expression pathway and was the focus of the 2013 annual Translation UK meeting held at the University of Kent. The meeting brought together scientists at all career...

View article titled, Control and regulation of mRNA translation

Articles

mRNA deadenylation by Pan2–Pan3

Jana Wolf, Lori A. Passmore

Biochem Soc Trans (2014) 42 (1): 184–187.

DOI: https://doi.org/10.1042/BST20130211

Published: 23 January 2014

... of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2–Pan3 deadenylation complex. 1...

View article titled, mRNA deadenylation by Pan2–Pan3

Articles

Challenges and obstacles related to solving the codon bias riddles

Tamir Tuller

Biochem Soc Trans (2014) 42 (1): 155–159.

DOI: https://doi.org/10.1042/BST20130095

Published: 23 January 2014

... to many other biological/medical questions/fields. 1 email tamirtul@post.tau.ac.il 12 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biological model codon bias gene expression gene translation systems biology Codon bias is defined...

View article titled, Challenges and obstacles related to solving the codon bias riddles

Articles

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

Richard D.W. Kelly, Shaun M. Cowley

Biochem Soc Trans (2013) 41 (3): 741–749.

DOI: https://doi.org/10.1042/BST20130010

Published: 23 May 2013

... that histone acetylation correlated with active gene expression [ 2 , 11 ]. The N-terminal tails of the core histones H3 and H4 are rich in lysine residues, which, being positively charged, promote both histone–DNA and histone–histone interactions innately, restricting access to the underlying DNA. Acetylation...

View article titled, The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

Articles

Human papillomavirus gene expression is controlled by host cell splicing factors

Tetyana Klymenko, Sheila V. Graham

Biochem Soc Trans (2012) 40 (4): 773–777.

DOI: https://doi.org/10.1042/BST20120079

Published: 20 July 2012

... are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle...

View article titled, Human papillomavirus gene expression is controlled by host cell splicing factors

Articles

How does Tra2β protein regulate tissue-specific RNA splicing?

David J. Elliott, Andrew Best, Caroline Dalgliesh, Ingrid Ehrmann, Sushma Grellscheid

Biochem Soc Trans (2012) 40 (4): 784–788.

DOI: https://doi.org/10.1042/BST20120036

Published: 20 July 2012

... Journal compilation © 2012 Biochemical Society 2012 development gene expression high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) RNA-binding proteins RNA splicing Tra2β transcriptome Alternative splicing introduces new coding information...

View article titled, How does Tra2β protein regulate tissue-specific RNA splicing?

Articles

Evolvement of LEM proteins as chromatin tethers at the nuclear periphery

Andreas Brachner, Roland Foisner

Biochem Soc Trans (2011) 39 (6): 1735–1741.

DOI: https://doi.org/10.1042/BST20110724

Published: 21 November 2011

... membrane are involved in tethering chromatin to the nuclear envelope and affect gene expression. They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, BAF (barrier to autointegration factor). Interestingly, this domain...

View article titled, Evolvement of LEM proteins as chromatin tethers at the nuclear periphery

Articles

Cytoplasmic mRNA: move it, use it or lose it!

Mark J. Coldwell, Nicola K. Gray, Matthew Brook

Biochem Soc Trans (2010) 38 (6): 1495–1499.

DOI: https://doi.org/10.1042/BST0381495

Published: 24 November 2010

... rapidly, as regulation of these multiple steps in gene expression is implicated in diverse aspects of biology such as metabolism, neurology, reproduction and viral lifecycle regulation. Researchers who utilize various combinations of human studies, animal models, cellular, genetic, biochemical...

View article titled, Cytoplasmic mRNA: move it, use it or lose it!

Articles

Myc up-regulates formation of the mRNA methyl cap

Victoria H. Cowling

Biochem Soc Trans (2010) 38 (6): 1598–1601.

DOI: https://doi.org/10.1042/BST0381598

Published: 24 November 2010

... methylation to be a therapeutic target. 1 email v.h.cowling@dundee.ac.uk 31 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell proliferation gene expression 7-methylguanosine cap mRNA translation c-Myc transcription The methyl cap is a 7...

View article titled, Myc up-regulates formation of the mRNA methyl cap

Articles

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?

Marta Vicente-Crespo, Isabel M. Palacios

Biochem Soc Trans (2010) 38 (6): 1500–1505.

DOI: https://doi.org/10.1042/BST0381500

Published: 24 November 2010

... of NMD in cellular growth and development of an organism. 1 To whom correspondence should be addressed (email mip22@cam.ac.uk ). 7 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression nonsense-mediated mRNA decay (NMD) premature...

View article titled, Nonsense-mediated mRNA decay and development: shoot the messenger to survive?

Articles

Cytoplasmic deadenylation: regulation of mRNA fate

Katrin Wiederhold, Lori A. Passmore

Biochem Soc Trans (2010) 38 (6): 1531–1536.

DOI: https://doi.org/10.1042/BST0381531

Published: 24 November 2010

...Katrin Wiederhold; Lori A. Passmore The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly...

View article titled, Cytoplasmic deadenylation: regulation of mRNA fate

Articles

The evolution of spliced leader trans -splicing in nematodes

Jonathan Pettitt, Neale Harrison, Ian Stansfield, Bernadette Connolly, Berndt Müller

Biochem Soc Trans (2010) 38 (4): 1125–1130.

DOI: https://doi.org/10.1042/BST0381125

Published: 26 July 2010

... ancestor with a diverse set of spliced leader RNA genes. eukaryote gene expression metazoan RNA processing RNA splicing SL trans -splicing in C. elegans is the subject of several excellent reviews [ 35 – 37 ]. Approx. 70% of C. elegans mRNAs are subject to SL trans -splicing to one of two...

View article titled, The evolution of spliced leader trans -splicing in nematodes

Articles

Gene Expression in Neuronal Disease

Ian C. Wood, Nicola K. Gray, Lesley Jones

Biochem Soc Trans (2009) 37 (6): 1261–1262.

DOI: https://doi.org/10.1042/BST0371261

Published: 19 November 2009

...Ian C. Wood; Nicola K. Gray; Lesley Jones The brain is the most complex organ of the body and it contains the greatest diversity of cell types. Collectively, the cells within the brain express the greatest number of genes encoded within our genome. Inappropriate gene expression within these cells...

View article titled, Gene Expression in Neuronal Disease

Articles

Whole genome expression as a quantitative trait

John Hardy, Danyah Trabzuni, Mina Ryten

Biochem Soc Trans (2009) 37 (6): 1276–1277.

DOI: https://doi.org/10.1042/BST0371276

Published: 19 November 2009

...John Hardy; Danyah Trabzuni; Mina Ryten Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases...

View article titled, Whole genome expression as a quantitative trait

Articles

Regulation of angiogenesis by ETS transcription factors

Anna M. Randi, Andrea Sperone, Nicola H. Dryden, Graeme M. Birdsey

Biochem Soc Trans (2009) 37 (6): 1248–1253.

DOI: https://doi.org/10.1042/BST0371248

Published: 19 November 2009

...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...

View article titled, Regulation of angiogenesis by ETS transcription factors

Articles

How do microRNAs regulate gene expression?

Ian G. Cannell, Yi Wen Kong, Martin Bushell

Biochem Soc Trans (2008) 36 (6): 1224–1231.

DOI: https://doi.org/10.1042/BST0361224

Published: 19 November 2008

...Ian G. Cannell; Yi Wen Kong; Martin Bushell miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational...

View article titled, How do microRNAs regulate gene expression?

Articles

Post-transcriptional regulation of gene expression by alternative 5′-untranslated regions in carcinogenesis

Laura Smith

Biochem Soc Trans (2008) 36 (4): 708–711.

DOI: https://doi.org/10.1042/BST0360708

Published: 22 July 2008

...Laura Smith Post-transcriptional regulation, via 5′-UTRs (5′-untranslated regions), plays an important role in the control of eukaryotic gene expression. Recent analyses of the mammalian transcriptome suggest that most of the genes express multiple alternative 5′-UTRs and inappropriate expression...

View article titled, Post-transcriptional regulation of gene expression by alternative 5′-untranslated regions in carcinogenesis

Articles

Gene expression is reduced in trans by inosine-containing dsRNA

A.D.J. Scadden

Biochem Soc Trans (2008) 36 (3): 534–536.

DOI: https://doi.org/10.1042/BST0360534

Published: 21 May 2008

... by I-dsRNA occurs both by reducing mRNA levels and by inhibiting of translation. This finding has important functional consequences for hyperediting by ADARs. adenosine deaminase that acts on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation...

View article titled, Gene expression is reduced in trans by inosine-containing dsRNA

Articles

Comet and cup genes in Drosophila spermatogenesis: the first demonstration of post-meiotic transcription

Carine Barreau, Elizabeth Benson, Helen White-Cooper

Biochem Soc Trans (2008) 36 (3): 540–542.

DOI: https://doi.org/10.1042/BST0360540

Published: 21 May 2008

... are detected after the meiotic divisions conform to the conventional pattern of transcription and translational repression in the testes. However, we have found 17 testis-specific genes, collectively named ‘comets’ and ‘cups’, with utterly unexpected patterns of gene expression that do not conform...

View article titled, Comet and cup genes in Drosophila spermatogenesis: the first demonstration of post-meiotic transcription

Articles

Recognition of nonsense mRNA: towards a unified model

Oliver Mühlemann

Biochem Soc Trans (2008) 36 (3): 497–501.

DOI: https://doi.org/10.1042/BST0360497

Published: 21 May 2008

...Oliver Mühlemann Among the different cellular surveillance mechanisms that ensure accurate gene expression, nonsense-mediated mRNA decay rapidly degrades mRNAs harbouring PTCs (premature translation-termination codons) and thereby prevents the accumulation of potentially deleterious proteins with C...

View article titled, Recognition of nonsense mRNA: towards a unified model

Articles

Amino acid metabolism, insulin secretion and diabetes

P. Newsholme, K. Bender, A. Kiely, L. Brennan

Biochem Soc Trans (2007) 35 (5): 1180–1186.

DOI: https://doi.org/10.1042/BST0351180

Published: 25 October 2007

... chronic exposure, specific amino acids may influence gene expression in the β-cell, which have an impact on insulin secretion and cellular integrity. Therefore amino acids may play a direct or indirect (via generation of putative messengers of mitochondrial origin) role in insulin secretion...

View article titled, Amino acid metabolism, insulin secretion and diabetes

Articles

The Kaposi's sarcoma-associated herpesvirus ORF57 protein: a pleurotropic regulator of gene expression

P. Malik, E.C. Schirmer

Biochem Soc Trans (2006) 34 (5): 705–710.

DOI: https://doi.org/10.1042/BST0340705

Published: 25 October 2006

...-associated herpesvirus). All herpesviruses are nuclear replicating viruses that subvert cellular processes such as nucleocytoplasmic transport for their advantage. For virus replication to take over the cell and produce lytic infection requires that virus gene expression outpace that of the host cell. KSHV...

View article titled, The Kaposi's sarcoma-associated herpesvirus ORF57 protein: a pleurotropic regulator of gene expression

Articles

Multiple chromatin modifications important for gene expression changes in cardiac hypertrophy

A.J. Bingham, L. Ooi, I.C. Wood

Biochem Soc Trans (2006) 34 (6): 1138–1140.

DOI: https://doi.org/10.1042/BST0341138

Published: 25 October 2006

... hypertrophy can result in heart failure. One characteristic of hypertrophy is the re-expression of genes that are normally only expressed during foetal heart development. Although the involvement of these changes in gene expression in hypertrophy has been known for some years, the mechanisms involved...

View article titled, Multiple chromatin modifications important for gene expression changes in cardiac hypertrophy

Articles

Transforming growth factor-β-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis

D.P. Ramji, N.N. Singh, P. Foka, S.A. Irvine, K. Arnaoutakis

Biochem Soc Trans (2006) 34 (6): 1141–1144.

DOI: https://doi.org/10.1042/BST0341141

Published: 25 October 2006

... cholesterol homoeostasis gene expression lipoprotein lipase (LPL) transforming growth factor-β (TGF-β) The TGF-β superfamily comprises over 30 members that include TGF-β and a number of related factors (e.g. activins, nodals, bone morphogenetic proteins/growth and differentiation factors) [ 1...

View article titled, Transforming growth factor-β-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis

Articles

Control of mRNA stability in eukaryotes

S.F. Newbury

Biochem Soc Trans (2006) 34 (1): 30–34.

DOI: https://doi.org/10.1042/BST0340030

Published: 20 January 2006

...S.F. Newbury mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes...

View article titled, Control of mRNA stability in eukaryotes

Articles

Organ specificity in the circadian control of plant gene expression

S. Sullivan, M. Shenton, H.G. Nimmo

Biochem Soc Trans (2005) 33 (5): 943–944.

DOI: https://doi.org/10.1042/BST0330943

Published: 26 October 2005

... rhythmically and have identified ‘clusters’ of metabolically related genes that are expressed at particular times of the day [ 2 ]. For example, several genes expressed in late subjective afternoon encode proteins that function in the storage, transport or utilization of sugars. The promoters of many genes...

View article titled, Organ specificity in the circadian control of plant gene expression

Articles

The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis

K. Daly, M.A. Cuff, F. Fung, S.P. Shirazi-Beechey

Biochem Soc Trans (2005) 33 (4): 733–735.

DOI: https://doi.org/10.1042/BST0330733

Published: 01 August 2005

... that a reduction in MCT1 expression, and hence butyrate transport, can lead to a reduction in the intracellular butyrate levels required to regulate gene expression. Collectively, our results highlight the important contribution of butyrate transport to the maintenance of tissue homoeostasis and disease prevention...

View article titled, The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis

Articles

Studying the consequences of immediate loss of gene function in the intestine: APC

A.R. Clarke

Biochem Soc Trans (2005) 33 (4): 665–666.

DOI: https://doi.org/10.1042/BST0330665

Published: 01 August 2005

... 1 email clarkear@cf.ac.uk 30 3 2005 © 2005 The Biochemical Society 2005 adenomatous polyposis coli (APC) β-catenin colorectal cancer gene expression We also analysed the total number of BrdUrd-positive cells at 24 h. This number should increase arithmetically through...

View article titled, Studying the consequences of immediate loss of gene function in the intestine: APC

Articles

DMBT1 expression and glycosylation during the adenoma–carcinoma sequence in colorectal cancer

C. Robbe, C. Paraskeva, J. Mollenhauer, J.C. Michalski, C. Sergi, A. Corfield

Biochem Soc Trans (2005) 33 (4): 730–732.

DOI: https://doi.org/10.1042/BST0330730

Published: 01 August 2005

... tony.corfield@bristol.ac.uk ). 31 3 2005 adenoma–carcinoma sequence colorectal cancer DMBT1 (deleted in malignant brain tumour-1) gene expression tumour suppressor Changes in the glycosylation of a variety of glycoproteins, including mucins and tumour-suppressor-gene products, feature...

View article titled, DMBT1 expression and glycosylation during the adenoma–carcinoma sequence in colorectal cancer

Articles

The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression

R.W.P. Smith, P. Malik, J.B. Clements

Biochem Soc Trans (2005) 33 (3): 499–501.

DOI: https://doi.org/10.1042/BST0330499

Published: 01 June 2005

...R.W.P. Smith; P. Malik; J.B. Clements The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post...

View article titled, The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression

Articles

The importance of butyrate transport to the regulation of gene expression in the colonic epithelium

M.A. Cuff, S.P. Shirazi-Beechey

Biochem Soc Trans (2004) 32 (6): 1100–1102.

DOI: https://doi.org/10.1042/BST0321100

Published: 26 October 2004

... important to the processes maintaining colonic tissue homoeostasis. 1 To whom correspondence should be addressed (email spsb@liv.ac.uk ). 13 7 2004 © 2004 The Biochemical Society 2004 dietary fibre gene expression intestine monocarboxylate nutrient transport Adaptation...

View article titled, The importance of butyrate transport to the regulation of gene expression in the colonic epithelium

Articles

Dietary lipids and gene expression

H.M. Roche

Biochem Soc Trans (2004) 32 (6): 999–1002.

DOI: https://doi.org/10.1042/BST0320999

Published: 26 October 2004

.... 1 email hmroche@tcd.ie 25 8 2004 © 2004 The Biochemical Society 2004 fatty acid gene expression insulin resistance metabolic syndrome nutrigenomics sterol-regulatory-element-binding protein 1c (SREPB-1c) tumour necrosis factor-α (TNF-α) Nutritional genomics...

View article titled, Dietary lipids and gene expression

Articles

Oscillations in transcription factor dynamics: a new way to control gene expression

D.E. Nelson, V. Sée, G. Nelson, M.R.H. White

Biochem Soc Trans (2004) 32 (6): 1090–1092.

DOI: https://doi.org/10.1042/BST0321090

Published: 26 October 2004

... To whom correspondence should be addressed (email mwhite@liv.ac.uk ). 2 7 2004 © 2004 The Biochemical Society 2004 gene expression NF-κB oscillations transcription A stone thrown into water gives rise to oscillating ripples leading to a lasting perturbation of the smooth...

View article titled, Oscillations in transcription factor dynamics: a new way to control gene expression

Articles

RNA processing and Arabidopsis flowering time control

G.G. Simpson, V. Quesada, I.R. Henderson, P.P. Dijkwel, R. Macknight, C. Dean

Biochem Soc Trans (2004) 32 (4): 565–566.

DOI: https://doi.org/10.1042/BST0320565

Published: 01 August 2004

... gordon.simpson@scri.sari.ac.uk ). 20 3 2004 © 2004 The Biochemical Society 2004 alternative polyadenylation floral transition gene expression The floral transition is complex, involving the integration of responses to environmental cues with an endogenous programme of development...

View article titled, RNA processing and Arabidopsis flowering time control

Articles

Adipocyte cholesterol balance in obesity

S. Le Lay, P. Ferré, I. Dugail

Biochem Soc Trans (2004) 32 (1): 103–106.

DOI: https://doi.org/10.1042/bst0320103

Published: 01 February 2004

... Society 2004 cholesterol traffic fat cell gene expression lipid droplet sterol-response-element-binding protein (SREBP) triacylglycerol Abbreviations used: LDL, low-density lipoprotein; SREBP, sterol-response-element-binding protein; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA...

View article titled, Adipocyte cholesterol balance in obesity

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