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Keywords: gene duplication
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Articles
Biochem Soc Trans (2020) 48 (4): 1353–1365.
Published: 05 August 2020
... venomous animals evolve from non-venomous animals, and how does this path effect the composition and pharmacology of the venom? What genetic processes (gene duplication, co-option, neofunctionalisation) are most important in toxin evolution? What kinds of selection pressures are acting on toxin-encoding...
Articles
Biochem Soc Trans (2014) 42 (6): 1709–1714.
Published: 17 November 2014
... to genetic and environmental perturbations enable the persistence of a reservoir of genetic variants, each potentially codifying for a distinct function. Gene duplication is one such mechanism that has characterized the expansion and has been concomitant with the emergence of novel functions in these protein...
Articles
Biochem Soc Trans (2014) 42 (6): 1684–1691.
Published: 17 November 2014
... a transcription factor that controls expression of either partner. The evolutionary history of each moonlighting protein is complex, depending on the stochastic occurrence of genetic changes such as gene duplication and point mutations, and the effects of those changes on fitness. Population effects, particularly...
Articles
Biochem Soc Trans (2009) 37 (4): 723–726.
Published: 22 July 2009
... sequences, structures and systems. Gene duplication, followed by gene fusion or fission, or exon shuffling can lead to new combinations of protein domains, and hence the potential for the creation of new proteins. Buljan and Bateman [ 15 ] show that most domain gains and losses occur at protein termini...
Articles
Biochem Soc Trans (2009) 37 (4): 778–782.
Published: 22 July 2009
... that many of them are probably involved in lineage-specific adaptive processes. One important question that has remained elusive to date is how orphan genes originate. It has been proposed that they might have arisen by gene duplication followed by a period of very rapid sequence divergence, which would...
Articles
Biochem Soc Trans (2009) 37 (4): 734–739.
Published: 22 July 2009
... million years, this results in only a small underestimation of ∼100 genes since the human mouse divergence [ 18 , 19 ]. The great majority of genes are thus gained in each lineage not by de novo creation or retrotransposition, but instead by whole gene duplication, often in tandem copies...
Articles
Biochem Soc Trans (2000) 28 (2): 259–264.
Published: 01 February 2000
...T.J. Gibson; J. Spring Vertebrate genomes are larger than invertebrates and show evidence of extensive gene duplication, including many collinear chromosomal segments. On the basis of this intra-genomic synteny, it has been proposed that two rounds of whole genome duplication (octaploidy) occurred...