... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . developmental biology functional genomics gene expression and regulation gene regulatory networks Multicellular organisms develop from a single fertilized egg, guided by the genetic information encoded in the genome...

...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cancer chemotherapy resistance functional genomics genetics Although initially focused on somatic mutations, recent work has revealed that more than 8% of cancers within the Cancer Genome Atlas have a strong...

... the Creative Commons Attribution License 4.0 (CC BY) . archaeal proteins computational biology functional genomics The drop of sequencing costs over the last decade has led to a dramatic increase in the influx of new genomes into public databases. Furthermore, unlike the preceding years, most...

... fission yeast functional genomics Schizosaccharomyces pombe transcriptional-regulatory network transcription factor Transcriptional-regulatory networks determine the global gene expression profiles that give rise to specific cellular processes and phenotypes. Central to the network...

...David A. Fell; Mark G. Poolman; Albert Gevorgyan Reconstructing a model of the metabolic network of an organism from its annotated genome sequence would seem, at first sight, to be one of the most straightforward tasks in functional genomics, even if the various data sources required were never...

...Ravishankar Palanivelu; Mark A. Johnson The pollen tube represents an attractive model system for functional genomic analysis of the cell–cell interactions that mediate guided cellular growth. The pollen tube extends through pistil tissues and responds to guidance cues that direct the tube towards...

... on the cell array format are expected to contribute to the acceleration of functional genomic studies. Integration of existing genome-wide gene expression data with simple functional protein properties, such as intracellular localization patterns, will lead to further elucidation of physiological...

... and abiotic characteristics in high-temperature habitats. Described here are functional genomics-based approaches, using cDNA microarrays, to gain insight into how ecological features such as biofilm formation, species interaction, and possibly even gene transfer may occur in native environments, as well...

... on native mRNAs, methods for ribozyme expression, and strategies for obtaining a discrete intracellular localization of ribozymes. 1 To whom correspondence should be addressed (e-mail jrossi@bricoh.edu ) 27 8 2002 © 2002 Biochemical Society 2002 cancer functional genomics...