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Keywords: frizzled
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Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
... for structure-based drug design efforts targeting canonical Wnt signalling. Figure 3. Structures related to interactions involving secreted negative regulators of Wnt signalling. ( A ) Secreted Frizzled-related proteins. Legend: grey — mouse sFRP3 cysteine-rich domain (PDB 1IJX); blue-white-red N-to-C...
Biochem Soc Trans (2015) 43 (2): 211–216.
Published: 07 April 2015
... and function. Intriguingly, the crystal structure of XWnt8 in complex with the extracellular domain of the Frizzled 8 cysteine-rich domain (Fzd8-CRD) revealed that Wnts use the fatty acid as a ‘hotspot’ residue to engage its receptor, which is a unique mode of receptor-ligand recognition. In addition...
Biochem Soc Trans (2004) 32 (5): 792–796.
Published: 26 October 2004
...H. Wang; Y. Lee; C.C. Malbon Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca 2+ /cGMP pathway mediated by Frizzled-2 was discovered recently. Activation...