...Paul G. Winyard; Corinne M. Spickett; Helen R. Griffiths The field of free radical biology and medicine continues to move at a tremendous pace, with a constant flow of ground-breaking discoveries. The following collection of papers in this issue of Biochemical Society Transactions highlights...

... oxygen species was monitored using the fluorescent dye DCFH-DA (2′,7′-dichlorofluorescein diacetate). It was shown that ferritin leads to a dose-dependent formation of free radicals. We found that the ferritin-mediated changes in glutamatergic neurotransmission at presynaptic endings can result...

...E. Neil G. Marsh Glutamate mutase is one of a group of adenosylcobalamin-dependent enzymes that use free radicals to catalyse unusual and chemically difficult rearrangements involving 1,2-migrations of hydrogen atoms. A key mechanistic feature of these enzymes is the transfer of the migrating...

... and offers potential for development of novel biomarkers of inflammatory diseases. In the present paper, we review some of the progress that has been made towards this goal. biomarker chlorohydrin chlorotyrosine free radical oxidative stress precursor-ion scanning HOCl is an oxidizing...

..., 30623 Hannover, Germany. 13 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes free radical oxidative stress pancreatic β-cell death reactive nitrogen species reactive oxygen species The pancreatic β-cell is in an extraordinary situation...

...E. Niki The oxidative modification of low-density lipoprotein (LDL) can be induced by various active species by different mechanisms. Vitamin E and other radical-scavenging antioxidants can inhibit the free radical-mediated oxidation of LDL, but they are not effective against LDL oxidation induced...

...R. Maeba; N. Ueta We have demonstrated a novel antioxidant action of ethanolamine plasmalogens both in protecting cholesterol from oxidation by free radicals and in lowering the oxidizability of membranes, along with the action of scavenging radicals, by the oxygen-uptake method using large...