... to synthesis of polyamines or radical formation. SAM is regenerated from demethylated SAM via the methionine cycle, which involves folate. Imbalance of this cycle in humans, e.g. through folate shortage via dietary insufficiency, alcohol abuse, arsenic poisoning or hereditary factors, leads to depletion of SAM...

..., and hence the colonic crypt within which it occurs. Preliminary studies with a rodent model suggest the rate of age-dependent methylation of ESR1 is modifiable by dietary folate. 1 To whom correspondence should be addressed (email nigel.belshaw@bbsrc.ac.uk ). 11 3 2005 © 2005...

... © 2004 The Biochemical Society 2004 aging cancer DNA methylation folate in utero development Nutritional insults during foetal and neonatal development are hypothesized to have a detrimental impact on adult morbidity and mortality [ 1 ], but the underlying mechanisms are poorly...