...@durham.ac.uk ). 26 7 2005 © 2005 The Biochemical Society 2005 endoplasmic reticulum oxidoreductase flavoprotein oxidoreductase protein disulphide-isomerase protein folding redox In eukaryotic cells, the ER (endoplasmic reticulum) provides an environment for secretory and outer...

... cell proliferation. Enzymes have evolved to catalyse these reactions and these oxidoreductases can be grouped into the flavoprotein and quinoprotein families. The mechanism of amine oxidation catalysed by the quinoprotein amine oxidases is understood reasonably well and occurs through the formation...

.... Both are soluble proteins. Thus it was initially envisaged that only two types of P450 redox systems might occur in nature: (i) a prokaryotic (class I) system consisting of three soluble components: an NADH-specific flavoprotein reductase that shuttled electrons to a soluble P450 via a ferredoxin...

... synthesis in numerous microbial species. Discovery of flavin-dependent thymidylate synthase ThyX Despite the fact that Pyrococcus abyssi, a hyperthermophilic anaerobic archeon, is unable to salvage thymidine from Key words: DNA evolution, flavoprotein, hyperthermophile, thymidylate synthase. Abbreviations...

... flavoprotein kinetics Abbreviations used: CPR, cytochrome P450 reductase; hq, hydroquinone; ox, oxidized; sq, semiquinone. Enzyme Mechanism A Structural Perspective 497 Electron transfer in human cytochrome P450 reductase A. Gutierrez*, A. Grunau*, M. Paine , A.W. Munro*, C.R. Wolf , G.C.K...

... systems. Apart from P450, these systems include a FAD flavoprotein or domain, a FMN domain, ferredoxins and cytochrome b 5 . Analysis of available complete genomes can shed light on what an ancestral P450-containing system could be. 1 To whom correspondence should be addressed (e-mail kirill...